Sherman W H, Olarte M R, McKiernan G, Sweeney K, Latov N, Hays A P
J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):813-9. doi: 10.1136/jnnp.47.8.813.
Plasma exchange was used to treat 10 patients with polyneuropathy and a monoclonal antibody (plasma cell dyscrasia). Six patients had improvement of the neuropathy, while three patients had stabilisation of the neuropathy during plasma exchange. The patients who improved maintained a 64% or greater decrease in the monoclonal antibody between exchanges. Patients with axonal polyneuropathy as well as patients with demyelinating polyneuropathy recovered some neurologic function. With cessation of plasma exchanges, the monoclonal antibody titre approached pre-treatment levels and the neuropathy progressed. Plasma exchange was effective in rapidly lowering the level of monoclonal antibody and allowing for some recovery of neurologic function.
血浆置换用于治疗10例患有多发性神经病和单克隆抗体（浆细胞发育异常）的患者。6例患者的神经病有所改善，而3例患者在血浆置换期间神经病病情稳定。病情改善的患者在两次置换之间单克隆抗体下降了64%或更多。轴索性多发性神经病患者以及脱髓鞘性多发性神经病患者恢复了一些神经功能。随着血浆置换的停止，单克隆抗体滴度接近治疗前水平，神经病病情进展。血浆置换在迅速降低单克隆抗体水平并使神经功能得到一定恢复方面是有效的。
