Buturović-Ponikvar Jadranka, Gubenšek Jakob, Arnol Miha, Bren Andrej, Kandus Aljoša, Ponikvar Rafael
Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Ther Apher Dial. 2011 Jun;15(3):245-9. doi: 10.1111/j.1744-9987.2011.00945.x.
Kidney transplantation is considered the best renal replacement therapy (RRT) for patients with end-stage renal disease; nevertheless, some dialysis patients refuse to be transplanted. The aim of our registry-based, cross-sectional study was to compare kidney transplant candidates to dialysis patients refusing transplantation. Data were collected from the Slovenian Renal Replacement Therapy Registry database, as of 31 December 2008. Demographic and some RRT data were compared between the groups. There were 1448 dialysis patients, of whom 1343 were treated by hemodialysis and 105 by peritoneal dialysis (PD); 132 (9%) were on the waiting list for transplantation, 208 (14%) were preparing for enrollment (altogether 340 [23%] dialysis patients were kidney transplant candidates); 200 (13.7%) patients were reported to refuse transplantation, all ≤ 65 years of age; 345 (24%) were not enrolled due to medical contraindications, 482 (33%) due to age, and 82 (6%) due to other or unknown reasons. No significant difference was found in age, gender, or presence of diabetes between kidney transplant candidates vs. patients refusing transplantation (mean age 50.5 ± 13.9 vs. 51.3 ± 9.6 years, males 61% vs. 63%, diabetics 18% vs. 17%). The proportion of patients ≤ 65 years old who were refusing transplantation was 28% (187/661) for hemodialysis and 17% (13/79) for PD patients (P = 0.03). There is a considerable group of dialysis patients in Slovenia refusing kidney transplantation. Compared to the kidney transplant candidates, they are similar in age, gender and prevalence of diabetes. Patients treated by peritoneal dialysis refuse kidney transplantation less often than hemodialysis patients.
肾移植被认为是终末期肾病患者最佳的肾脏替代治疗（RRT）；然而，一些透析患者拒绝接受移植。我们这项基于登记处的横断面研究旨在比较肾移植候选者与拒绝移植的透析患者。数据收集自斯洛文尼亚肾脏替代治疗登记处数据库，截至2008年12月31日。对两组之间的人口统计学和一些肾脏替代治疗数据进行了比较。共有1448例透析患者，其中1343例接受血液透析治疗，105例接受腹膜透析（PD）治疗；132例（9%）在等待移植名单上，208例（14%）正在准备登记（总计340例[23%]透析患者为肾移植候选者）；200例（13.7%）患者被报告拒绝移植，所有患者年龄均≤65岁；345例（24%）因医学禁忌未登记，482例（33%）因年龄原因未登记，82例（6%）因其他或不明原因未登记。肾移植候选者与拒绝移植的患者在年龄、性别或糖尿病患病率方面未发现显著差异（平均年龄50.5±13.9岁对51.3±9.6岁，男性分别为61%对63%，糖尿病患者分别为18%对17%）。年龄≤65岁拒绝移植的患者中，血液透析患者占28%（187/661），腹膜透析患者占17%（13/79）（P=0.03）。在斯洛文尼亚，有相当一部分透析患者拒绝肾移植。与肾移植候选者相比，他们在年龄、性别和糖尿病患病率方面相似。接受腹膜透析治疗的患者拒绝肾移植的频率低于接受血液透析的患者。
