Wu Xue-jun, Huang Ying, Wang Ying, Gong Cai-hui
Children's Hospital of Chongqing Medical University Key Laboratory of Developmental Diseases in Childhood (Chongqing Medical University), Ministry of Education, Chongqing 400014, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Mar;45(3):255-8.
To investigate the relationship between moderate-severe asthma and development in children.
A total of 389 children in the state of moderate-severe persistent asthma were enrolled, which were divided into moderate (226 cases) and severe group (163 cases). According to age, each group was divided into three groups: 3-year-old (85 cases and 63 cases), 5-year-old (76 cases and 52 cases) and 7 to 10 year-old (65 cases and 48 cases). Meanwhile, 298 healthy children in the same age group were enrolled as control, of which 3-year-old were 96 cases, 5-year-old were 92 cases and 7 to 10 year-old were 110 cases. Height, weight and lung function were measured respectively.
3-year-old of severe group, the value of height, the value of weight, the percentage of height, the percentage of weight, the SDS of height, the SDS of weight [(98.54 ± 7.75) cm, (14.87 ± 2.46) kg, 50.30% ± 16.31%, 50.27% ± 18.29%, 0.11 ± 0.66, 0.06 ± 0.49, respectively] were lower than the moderate group of the same age group ((103.58 ± 5.48) cm, (16.60 ± 2.21) kg, 65.80% ± 18.54%, 65.10% ± 18.92%, 0.46 ± 0.53, 0.45 ± 0.54, respectively) and the control group ((105.60 ± 6.29) cm, (17.82 ± 2.82) kg, 72.37% ± 11.37%, 71.92% ± 2.82%, 0.66 ± 0.62, 0.66 ± 0.52), the difference was significant (F values were 7.295, 8.034, 15.246, 10.745, 8.026, 10.864, respectively, P < 0.05).5-years of severe group, the value of height, the value of weight, the percentage of height, the percentage of weight, the SDS of height, the SDS of weight ((110.10 ± 7.36) cm, (18.76 ± 3.20) kg, 45.86% ± 18.92%, 41.69% ± 12.50%, -0.95 ± 0.42, -0.23 ± 0.34, respectively) were lower than the moderate group of the same age group ((117.76 ± 6.35) cm, (21.63 ± 2.75) kg, 61.81% ± 20.75%, 61.79% ± 18.92%, 0.36 ± 0.62, 0.38 ± 0.56) and the control group ((119.90 ± 5.78) cm, (22.80 ± 3.07) kg, 68.97% ± 18.59%, 66.27% ± 18.35%, 0.57 ± 0.65, 0.48 ± 0.63), the difference was significant (F values were 8.351, 7.864, 15.037, 13.921, 12.116, 11.725, respectively, P < 0.05).7 to 10 years-old of severe group, the value of height, the value of weight, the percentage of height, the percentage of weight, the SDS of height, the SDS of weight ((123.50 ± 9.52) cm, (23.82 ± 5.72) kg, 45.81% ± 15.51%, 42.63% ± 14.91%, -0.06 ± 0.48, -0.02 ± 0.61, respectively) were lower than the moderate group of the same age group ((129.1 ± 8.41) cm, (26.70 ± 5.72) kg, 66.84% ± 16.09%, 64.07% ± 18.58%, 0.48 ± 0.46, 0.42 ± 0.49) and the control group ((131.87 ± 7.71) cm, (28.06 ± 6.01) kg, 71.44% ± 12.70%, 69.64% ± 16.20%, 0.60 ± 0.43, 0.60 ± 0.51), the difference was significant(F values were 6.136, 6.678, 57.316, 37.893, 37.210, 34.152, respectively, P < 0.05). 3-, 5-, 7 to 10 year-old of moderate group, the value of height, the value of weight, the percentage of height, the percentage of weight, the SDS of height, the SDS of weight dropped compared to the control group of the same age, but no significant difference was found (t values were -2.008, -1.988, -1.810, -1.879, -1.713, -1.844, -1.904, -2.019, -1.605, -1.017, -1.411, -0.713, -1.881, -1.896, -1.746, -1.906, -1.523, -1.864, respectively, P > 0.05).
The height and weight of children with severe asthma were lower than those of normal children or with moderate asthma.
探讨中重度哮喘与儿童发育之间的关系。
共纳入389例中重度持续性哮喘患儿，分为中度组（226例）和重度组（163例）。根据年龄，每组又分为3岁组（85例和63例）、5岁组（76例和52例）以及7至10岁组（65例和48例）。同时，纳入298例同年龄组的健康儿童作为对照组，其中3岁组96例，5岁组92例，7至10岁组110例。分别测量身高、体重和肺功能。
重度组3岁患儿的身高值、体重值、身高百分比、体重百分比、身高标准差、体重标准差[分别为(98.54±7.75)cm、(14.87±2.46)kg、50.30%±16.31%、50.27%±18.29%、0.11±0.66、0.06±0.49]低于同年龄组的中度组[(分别为(103.58±5.48)cm、(16.60±2.21)kg、65.80%±18.54%、65.10%±18.92%、0.46±0.53、0.45±0.54]和对照组[(分别为(105.60±6.29)cm、(17.82±2.82)kg、72.37%±11.37%、71.92%±2.82%、0.66±0.62、0.66±0.52]，差异有统计学意义（F值分别为7.295、8.034、15.246、10.745、8.026、10.864，P<0.05）。重度组5岁患儿的身高值、体重值、身高百分比、体重百分比、身高标准差、体重标准差[(分别为(110.10±7.36)cm、(18.76±3.20)kg、45.86%±18.
