Computational Biology, GlaxoSmithKline R&D, King of Prussia, PA 19406, USA.
Drug Discov Today. 2011 Jul;16(13-14):594-9. doi: 10.1016/j.drudis.2011.05.009. Epub 2011 May 23.
Electronic health records (EHRs) have increased in popularity in many countries. Pushed by legal mandates, EHR systems have seen substantial progress recently, including increasing adoption of standards, improved medical vocabularies and enhancements in technical infrastructure for data sharing across healthcare providers. Although the progress is directly beneficial to patient care in a hospital or clinical setting, it can also aid drug discovery. In this article, we review three specific applications of EHRs in a drug discovery context: finding novel relationships between diseases, re-evaluating drug usage and discovering phenotype-genotype associations. We believe that in the near future EHR systems and related databases will impact significantly how we discover and develop safe and efficacious medicines.
电子健康记录（EHR）在许多国家越来越受欢迎。在法律要求的推动下，EHR 系统最近取得了重大进展，包括越来越多地采用标准、改进医疗词汇以及增强医疗保健提供者之间数据共享的技术基础设施。尽管这一进展直接有益于医院或临床环境中的患者护理，但它也有助于药物发现。在本文中，我们回顾了 EHR 在药物发现背景下的三个具体应用：发现疾病之间的新关系、重新评估药物使用和发现表型-基因型关联。我们相信，在不久的将来，EHR 系统和相关数据库将显著影响我们发现和开发安全有效的药物的方式。
