Vorob'ev V V, Gal'chenko A A
Farmakol Toksikol. 1988 Jan-Feb;51(1):26-8.
The effect of ketamine (80 mg/kg, intraperitoneally) on the frequency composition of electrograms of the visual and somatosensory regions of the cerebral cortex, hippocampus and medial nuclei of the hypothalamus was studied in chronic experiments on rats. An increase of the power of 4 Hz fluctuations and a decrease of 6 Hz fluctuations were noted in all structures. Ten min. after the drug injection the effect of 4 Hz rhythm enhancement was sharply suppressed (except the visual cortex). A combined administration of 5-hydroxytryptophan (30 mg/kg) and alpha-methyl-dihydroxyphenylalanine (100 mg/kg) resulted in the occurrence on the visual cortex of the effects similar to those produced by ketamine.
在大鼠慢性实验中，研究了氯胺酮（80毫克/千克，腹腔注射）对大脑皮层视觉和体感区域、海马体以及下丘脑内侧核电图频率组成的影响。在所有结构中均观察到4赫兹波动功率增加，6赫兹波动功率降低。注射药物10分钟后，4赫兹节律增强的效应被急剧抑制（视觉皮层除外）。联合给予5-羟色氨酸（30毫克/千克）和α-甲基二羟基苯丙氨酸（100毫克/千克）会在视觉皮层产生与氯胺酮相似的效应。
