从络石藤的地上部分中得到的一个新的黄酮类糖苷。
A new isoflavonoid glycoside from the aerial parts of Trachelospermum jasminoides.
机构信息
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.
出版信息
Chin J Nat Med. 2013 May;11(3):274-6. doi: 10.1016/S1875-5364(13)60028-X.
AIM
To study the chemical constituents from the aerial parts of Trachelospermum jasminoides.
METHODS
Compounds were isolated by various chromatographic methods and their structures were elucidated on the basis of spectral techniques. In addition, the inhibitory activity against HepG2 and HL-60 of compound 1 was evaluated.
RESULTS
Five compounds were isolated and identified as 3', 7-dimethoxyisoflavanone-4', 5-di-O-β-D-glucopyranoside (1), tracheloside (2), nortrachelogenin 5'-C-β-glucopyranoside (3), luteolin-4'-O-β-D-rutinoside (4), and luteolin-7-O-β-D-glucopyranoside (5).
CONCLUSION
Compound 1 is a new isoflavonoid glycoside. It showed weak inhibitory activity against HepG2 and HL-60 cancer cells with IC50 values of 131.5 and 58.2 μmol·L(-1), respectively.
目的
研究络石藤地上部分的化学成分。
方法
采用各种色谱方法进行化合物分离，并根据光谱技术解析其结构。此外，还评价了化合物 1 对 HepG2 和 HL-60 的抑制活性。
结果
分离并鉴定了 5 个化合物，分别为 3',7-二甲氧基异黄酮-4',5-二-O-β-D-吡喃葡萄糖苷（1）、络石苷（2）、络石苷元 5'-C-β-吡喃葡萄糖苷（3）、木樨草素-4'-O-β-D-芦丁糖苷（4）和木樨草素-7-O-β-D-吡喃葡萄糖苷（5）。
结论
化合物 1 是一种新的异黄酮糖苷。它对 HepG2 和 HL-60 癌细胞表现出较弱的抑制活性，IC50 值分别为 131.5 和 58.2 μmol·L(-1)。
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