Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, #325, Section 2, Chenggung Road, Neihu 114, Taipei, Taiwan, Republic of China.
J Anesth. 2011 Aug;25(4):606-8. doi: 10.1007/s00540-011-1148-x. Epub 2011 May 29.
The most frequent causes of anaphylaxis during anesthesia are neuromuscular blocking agents, antibiotics, and latex. Proton pump inhibitors (PPI) are widely used during major surgery for the prevention of stress ulcers, but cases of perioperative anaphylactic reactions to these have rarely been reported. We present a 50-year-old male patient who experienced an episode of anaphylaxis with hypoxemia, hypotension, tachycardia, and generalized erythema after intravenous injection of pantoprazole 40 mg and methylprednisolone 1 g during general anesthesia. After resuscitation, the patient recovered without any sequelae. Six months after the surgery, a skin test was positive to pantoprazole.
在麻醉期间，最常见的过敏反应原因是神经肌肉阻滞剂、抗生素和乳胶。质子泵抑制剂（PPI）在大手术中被广泛用于预防应激性溃疡，但这些药物在围手术期引起过敏反应的情况很少见。我们报告了一例 50 岁男性患者，在全身麻醉期间静脉注射泮托拉唑 40mg 和甲基强的松龙 1g 后，出现过敏反应伴低氧血症、低血压、心动过速和全身性红斑。复苏后，患者无任何后遗症恢复。手术后 6 个月，皮肤试验对泮托拉唑呈阳性。
