Department of Surgery, University of Cincinnati, Cincinnati, OH 45267, USA.
Hepatology. 2011 Oct;54(4):1445-53. doi: 10.1002/hep.24457. Epub 2011 Jun 29.
The process of liver repair and regeneration following hepatic injury is complex and relies on a temporally coordinated integration of several key signaling pathways. Pathways activated by members of the CXC family of chemokines play important roles in the mechanisms of liver repair and regeneration through their effects on hepatocytes. However, little is known about the signaling pathways used by CXC chemokine receptors in hepatocytes. Here we review our current understanding of the pathways involved in both CXC chemokine receptor signaling in other cell types, most notably neutrophils, and similar pathways operant during hepatocyte proliferation/liver regeneration to formulate a basis for the function of CXC chemokine receptor signaling in hepatocytes.
肝脏损伤后肝脏修复和再生的过程很复杂，依赖于几个关键信号通路的时间协调整合。CXC 趋化因子家族成员激活的通路通过对肝细胞的作用在肝脏修复和再生机制中发挥重要作用。然而，关于 CXC 趋化因子受体在肝细胞中使用的信号通路知之甚少。在这里，我们回顾了我们目前对 CXC 趋化因子受体在其他细胞类型（尤其是中性粒细胞）中的信号通路的理解，以及在肝细胞增殖/肝脏再生过程中发挥作用的类似通路，为 CXC 趋化因子受体信号在肝细胞中的功能制定了基础。
