Bhawan J, Bacchetta C, Joris I, Majno G
Am J Pathol. 1979 Jan;94(1):19-36.
Infantile digital fibromas are distinctive tumors both clinically and morphologically. A unique light microscopic features in the presence of intracytoplasmic, spherical, eosinophilic inclusion bodies. Previous electron microscopic studies have shown these bodies to consist of fibrils; bundles of fibrils have also been described in the cytoplasm. We have examined one such tumor, confirmed earlier findings, and established that the component cells are typical myofibroblasts. The latter are a variety of fibroblasts first described in granulation tissue; they are endowed with contractile properties and are characterized ultrastructurally by bundles of fibrils containing "dense bodies" such as are found in smooth muscle cells. Since our case is identical to those previously described, we propose that this tumor be called infantile digital myofibroblastoma.
婴儿指部纤维瘤在临床和形态学上都是独特的肿瘤。其独特的光镜特征是存在胞浆内球形嗜酸性包涵体。以往的电镜研究显示这些包涵体由原纤维组成；胞浆内也有原纤维束的描述。我们检查了一例这样的肿瘤，证实了早期的发现，并确定其组成细胞为典型的肌成纤维细胞。后者是在肉芽组织中首次描述的一种成纤维细胞；它们具有收缩特性，超微结构特征是含有“致密小体”的原纤维束，如同在平滑肌细胞中所见。由于我们的病例与先前描述的病例相同，我们建议将此肿瘤称为婴儿指部肌成纤维细胞瘤。
