Department of Biochemistry, Rabiammal Ahmed Maideen College for Women, Tamilnadu, India.
Clin Exp Hypertens. 2011;33(7):437-43. doi: 10.3109/10641963.2010.549259. Epub 2011 May 31.
In humans, hypertension is considered a state of oxidative stress that can contribute to the development of atherosclerosis and other hypertension-induced organ damages. The objective of this study was to evaluate oxidative status, antioxidant activities, and oxidative stress by-products among Indian patients with various stages of hypertension. Lipid profile, enzymatic and non-enzymatic antioxidants, lipid peroxidation as thiobarbituric acid reactive substances (TBARS), C-reactive protein, electrolytes, and minerals were analyzed in the blood of newly diagnosed prehypertensives, stage I and II hypertensives (n = 20 in each group) and were compared to their age-matched normotensives. Elevated levels of lipid profile (except high density lipoprotein cholesterol [HDL-C]) were observed in stage I and II hypertensive patients. Enzymatic and non-enzymatic antioxidants were significantly (P < 0.05) lower, while TBARS and C-reactive protein were higher in prehypertensives, and stage I and II hypertensives. Significant (P <0.05) changes were also observed in the plasma Na(+) and K(+) concentrations among the hypertensive groups. Serum levels of zinc, copper, and magnesium were significantly (P < 0.05) lower in prehypertensives, and stage I and II hypertensives as compared to normotensives. The study indicated a strong association between blood pressure (BP) and oxidative stress-related parameters and suggests a possible role of oxidative stress in the development of elevated BP.
在人类中，高血压被认为是一种氧化应激状态，可导致动脉粥样硬化和其他高血压引起的器官损伤的发展。本研究的目的是评估印度不同高血压阶段患者的氧化状态、抗氧化活性和氧化应激产物。在新诊断的高血压前期、I 期和 II 期高血压患者（每组 20 例）的血液中分析了血脂谱、酶和非酶抗氧化剂、脂质过氧化产物如硫代巴比妥酸反应物质（TBARS）、C 反应蛋白、电解质和矿物质，并与年龄匹配的血压正常者进行了比较。I 期和 II 期高血压患者的血脂谱水平升高（高密度脂蛋白胆固醇[HDL-C]除外）。酶和非酶抗氧化剂显著降低（P <0.05），而高血压前期患者和 I 期和 II 期高血压患者的 TBARS 和 C 反应蛋白升高。高血压组的血浆 Na（+）和 K（+）浓度也发生了显著变化（P <0.05）。与血压正常者相比，高血压前期患者和 I 期和 II 期高血压患者的血清锌、铜和镁水平显著降低（P <0.05）。该研究表明血压（BP）与氧化应激相关参数之间存在很强的关联，并提示氧化应激可能在高血压的发生中起作用。
