INSERM U1003, Equipe Labellisee par la Ligue Nationale Contre le Cancer, Universite de Sciences et Technologies de Lille (USTL), F-59655 Villeneuve d'Ascq, France.
Cell Calcium. 2011 Sep;50(3):295-302. doi: 10.1016/j.ceca.2011.05.006. Epub 2011 May 31.
TRP channels form a superfamily of channel proteins exhibiting versatile regulatory characteristics with many channels participating in the regulation of Ca(2+) homeostasis and influencing the cell fate. Multitude of evidence is emerging that the colocalization of TRP channels with Ca(2+)-sensing elements of specific regulatory pathways leading to either proliferation or apoptosis is what makes these channels participate in cell fate regulation and, in turn, determines the final effect of Ca(2+) entry via the particular channel. This review focuses on the aspects of TRP channel localization and function that affect the balance between cell survival and death and how various dysregulations of these channels may lead to perturbed balance and onset of cancer.
TRP 通道形成了一个通道蛋白超家族，具有多种调节特性，许多通道参与钙稳态的调节，并影响细胞命运。越来越多的证据表明，TRP 通道与特定调节途径的钙敏感受体的共定位导致细胞增殖或凋亡，这使得这些通道参与细胞命运调节，并反过来决定通过特定通道的钙内流的最终效应。本综述重点讨论了影响细胞存活和死亡平衡的 TRP 通道定位和功能的各个方面，以及这些通道的各种失调如何导致平衡失调和癌症的发生。
