Dokkyo Medical University, Japan.
Cephalalgia. 2011 Jul;31(9):1023-8. doi: 10.1177/0333102411410612. Epub 2011 May 31.
Peculiar characteristics of migraine headaches include the arousal of olfaction during the attacks and osmophobia. We performed an olfactory test to evaluate the association between olfaction and migraines.
We evaluated olfactory dysfunction in 80 migraine patients (31 experienced migraines with aura (MWA), 49 migraine without aura (MWOA)) and 30 healthy controls. Participants were assessed for concurrent osmophobia. Olfaction was evaluated using an odour stick identification test (OSIT), in which participants were asked to identify various odours during a migraine-free period. The degree of offensiveness of each odour was also evaluated.
Sixty-three percent of migraine patients were found to have concurrent osmophobia (MWA 71%; MWOA 57%). The percentages of migraine patients and controls who correctly identified test odours were 91% (92%, MWA; 89%, MWOA) and 92%, respectively. Perfume, rose and Japanese cypress odours were more offensive to migraine patients than to controls. All test odours were found to be more offensive to MWA than to MWOA patients.
The OSIT showed certain odours to be highly offensive to migraine patients even when they were not experiencing migraine headaches. More attention should be paid to odours that are perceived to be offensive by migraine patients, particularly those with MWA.
偏头痛的特点包括发作时嗅觉的觉醒和嗅觉恐惧症。我们进行了嗅觉测试，以评估嗅觉与偏头痛之间的关系。
我们评估了 80 名偏头痛患者（31 名有先兆偏头痛（MWA），49 名无先兆偏头痛（MWOA））和 30 名健康对照者的嗅觉功能障碍。评估了同期的嗅觉恐惧症。使用气味棒识别测试（OSIT）评估嗅觉，参与者在无偏头痛期识别各种气味。还评估了每种气味的令人反感的程度。
63%的偏头痛患者伴有同期嗅觉恐惧症（MWA 为 71%；MWOA 为 57%）。偏头痛患者和对照组正确识别测试气味的百分比分别为 91%（92%，MWA；89%，MWOA）和 92%。与对照组相比，偏头痛患者对香水、玫瑰和日本柏油气味更反感。与 MWOA 患者相比，所有测试气味均被发现对 MWA 患者更具攻击性。
OSIT 显示，即使偏头痛患者没有偏头痛发作，某些气味也会让他们感到非常不适。应更加关注偏头痛患者感知到的令人反感的气味，尤其是那些有 MWA 的患者。
