Miles K A, Williams R E, Yu D, Griffiths M R
Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9RH, UK.
Int J Mol Imaging. 2011;2011:679473. doi: 10.1155/2011/679473. Epub 2011 Apr 26.
Purpose. To assess whether the differences in vascular-metabolic relationships between lymphoma masses and colorectal liver metastases predicted from previous histopathological studies can be demonstrated by dynamic contrast-enhanced CT (DCE-CT) combined with fluorodeoxyglucose positron emission tomography (FDG-PET). Methods. DCE-CT and FDG-PET studies were drawn from an imaging archive for patients with either lymphoma masses (n = 11) or hepatic metastases from colorectal cancer (CRM: n = 12). Tumour vascularity was assessed using DCE-CT measurements of perfusion. Tumour glucose metabolism was expressed as the mean FDG Standardised Uptake Value (SUV(FDG)). The relationship between metabolism and vascularity in each group was assessed from SUV(FDG) /perfusion ratios and Pearson correlation coefficients. Results. An SUV(FDG) threshold of 3.0 was used to designate lymphoma masses as active (AL, n = 6) or inactive lymphoma (IL, n = 5). Tumour perfusion was significantly higher in AL (0.65 mL/min/mL) than CRM (0.37 mL/min/mL: P = .031) despite similar SUV(FDG) (5.05 and 5.33, resp.). AL demonstrated higher perfusion values than IL (0.24 mL/min/mL: P = .006). SUV(FDG)/perfusion was significantly higher in CRM (15.3 min) than IL (4.2 min, P < .01). There was no correlation between SUV(FDG) and perfusion for any patient group.
目的。评估先前组织病理学研究预测的淋巴瘤肿块与结直肠癌肝转移之间血管代谢关系的差异是否可通过动态对比增强CT（DCE-CT）联合氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）得以证实。方法。DCE-CT和FDG-PET研究数据取自影像存档，涉及淋巴瘤肿块患者（n = 11）或结直肠癌肝转移患者（CRM：n = 12）。使用DCE-CT灌注测量评估肿瘤血管生成。肿瘤葡萄糖代谢以平均FDG标准化摄取值（SUV(FDG)）表示。通过SUV(FDG)/灌注比值和Pearson相关系数评估每组中代谢与血管生成之间的关系。结果。使用SUV(FDG)阈值3.0将淋巴瘤肿块分为活性淋巴瘤（AL，n = 6）或惰性淋巴瘤（IL，n = 5）。尽管SUV(FDG)相似（分别为5.05和5.33），但AL的肿瘤灌注（0.65 mL/min/mL）显著高于CRM（0.37 mL/min/mL：P = .031）。AL的灌注值高于IL（0.24 mL/min/mL：P = .006）。CRM的SUV(FDG)/灌注（15.3分钟）显著高于IL（4.2分钟，P < .01）。任何患者组的SUV(FDG)与灌注之间均无相关性。
