胶质母细胞瘤伴少突胶质成分（GBMO）的分子和临床分析。
Molecular and clinical analysis of glioblastoma with an oligodendroglial component (GBMO).
机构信息
Department of Neurosurgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
出版信息
Brain Tumor Pathol. 2011 Jul;28(3):185-90. doi: 10.1007/s10014-011-0039-z. Epub 2011 Jun 1.
The genetic and clinical features of glioblastoma with an oligodendroglial component (GBMO), pathologically defined as anaplastic oligo-astrocytoma with necrosis, remain unclear. We investigated the correlation between genetic alterations and clinical outcomes in 19 GBMO patients we have encountered since 1997. Using single nucleotide polymorphism oligonucleotide genomic (SNP) microarrays, we analyzed gene amplification, loss of heterozygosity (LOH), and homozygous deletions in their whole genome. We also analyzed their overall survival (OS). Pathological studies revealed the presence of calcification in 11 and of a cyst in 9 of the 19 patients. Whole-genome analysis using SNP microarrays revealed LOH of chromosome 10 in 11, EGFR amplification in 8, 9p21 (INK4 locus) deletion in 12, PDGFR amplification in 2, and LOH of 1p19q in 2 patients. Median OS was 14 months (average 22.8 months). The pattern of genetic alterations was similar in GBMO and glioblastoma multiforme (GBM) patients, and the clinical outcomes were similar in GBMO and GBM patients.
具有少突胶质细胞成分的胶质母细胞瘤（GBMO）的遗传和临床特征，病理上定义为伴有坏死的间变性少突星形细胞瘤，目前仍不清楚。自 1997 年以来，我们共遇到 19 例 GBMO 患者，本研究旨在探讨这些患者的遗传改变与临床结局的相关性。我们使用单核苷酸多态性寡核苷酸基因组（SNP）微阵列分析了整个基因组中的基因扩增、杂合性丢失（LOH）和纯合性缺失。我们还分析了他们的总生存期（OS）。病理研究发现 19 例患者中有 11 例存在钙化，9 例存在囊肿。使用 SNP 微阵列进行全基因组分析显示，11 例患者存在 10 号染色体 LOH，8 例患者存在 EGFR 扩增，12 例患者存在 9p21（INK4 基因座）缺失，2 例患者存在 PDGFR 扩增，2 例患者存在 1p19q LOH。中位 OS 为 14 个月（平均 22.8 个月）。GBMO 和胶质母细胞瘤多形性（GBM）患者的遗传改变模式相似，GBMO 和 GBM 患者的临床结局也相似。
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