Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan.
Langmuir. 2011 Jul 5;27(13):8424-9. doi: 10.1021/la200861e. Epub 2011 Jun 1.
We describe a simple and effective method to obtain colloidal surface-functionalized Au nanoparticles. The method is primarily based on irradiation of a gold solution with high-flux X-rays from a synchrotron source in the presence of 11-mercaptoundecanoic acid (MUA). Extensive tests of the products demonstrated high colloidal density as well as excellent stability, shelf life, and biocompatibility. Specific tests with X-ray diffraction, UV-visible spectrometry, visible microscopy, Fourier transform infrared spectroscopy, dark-field visible-light scattering microscopy, and transmission electron microscopy demonstrated that MUA, being an effective surfactant, not only allows tunable size control of the nanoparticles, but also facilitates functionalization. The nanoparticle sizes were 6.45 ± 1.58, 1.83 ± 1.21, 1.52 ± 0.37 and 1.18 ± 0.26 nm with no MUA and with MUA-to-Au ratios of 1:2, 1:1, and 3:1. The MUA additionally enabled functionalization with l-glycine. We thus demonstrated flexibility in controlling the nanoparticle size over a large range with narrow size distribution.
我们描述了一种简单有效的方法来获得胶体表面功能化的金纳米粒子。该方法主要基于在 11-巯基十一酸（MUA）存在下，用同步加速器源的高通量 X 射线辐照金溶液。对产物的广泛测试表明，胶体具有高的密度以及优异的稳定性、保质期和生物相容性。X 射线衍射、紫外可见分光光度法、可见显微镜、傅里叶变换红外光谱、暗场可见光散射显微镜和透射电子显微镜的特定测试表明，MUA 作为一种有效的表面活性剂，不仅允许对纳米粒子的尺寸进行可调的控制，还便于功能化。没有 MUA 和 MUA 与 Au 的比例为 1:2、1:1 和 3:1 时，纳米粒子的尺寸分别为 6.45±1.58nm、1.83±1.21nm、1.52±0.37nm 和 1.18±0.26nm。MUA 还能够进行 L-甘氨酸的功能化。因此，我们证明了在较宽的范围内具有窄的尺寸分布来控制纳米粒子尺寸的灵活性。
