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通过检测负载金纳米颗粒的细胞对活鼠体内肿瘤生长进行 X 射线成像。

X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells.

机构信息

Institute of Physics, Academia Sinica, Nankang, Taipei 115, Taiwan.

出版信息

Sci Rep. 2012;2:610. doi: 10.1038/srep00610. Epub 2012 Aug 29.

DOI:10.1038/srep00610
PMID:22934133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3429882/
Abstract

We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach.

摘要

我们表明，通过原始合成方法在 EMT-6 和 CT-26 癌细胞中产生的足够浓度的金纳米粒子使得有可能在活小鼠接种后检测到这些细胞的存在、坏死和增殖。我们首先证明了纳米粒子不会干扰增殖过程。然后，我们观察到浅和深接种后肿瘤演变和血管生成过程的显著差异。与病理学光学图像的直接比较说明了这种方法的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/49dd20cc92a1/srep00610-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/2e06f0d4f9b2/srep00610-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/3fcd5c5f8b93/srep00610-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/70475572d515/srep00610-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/69d3ac957f20/srep00610-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/49dd20cc92a1/srep00610-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/2e06f0d4f9b2/srep00610-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/3fcd5c5f8b93/srep00610-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/70475572d515/srep00610-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/69d3ac957f20/srep00610-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2686/3429882/49dd20cc92a1/srep00610-f5.jpg

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