芳基炔与 N-对甲苯磺酰腙的 3-取代吲哚合成。
Synthesis of 3-substituted indazoles from arynes and N-tosylhydrazones.
机构信息
Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Jinming Campus, Kaifeng, 475004, PR China.
出版信息
Org Lett. 2011 Jul 1;13(13):3340-3. doi: 10.1021/ol201086g. Epub 2011 Jun 1.
PMID:21630698
Abstract
Readily available, stable, and inexpensive N-tosylhydrazones react with arynes under mild reaction conditions to afford 3-substituted indazoles in moderate to good yields. The reaction appears to involve a dipolar cycloaddition of in situ generated diazo compounds and arynes.
摘要
易于获得、稳定且廉价的 N-对甲苯磺酰腙在温和的反应条件下与芳基炔反应，以中等至良好的收率得到 3-取代的吲唑。该反应似乎涉及到原位生成的重氮化合物和芳基炔的双极性环加成。
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