Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
Virology. 2011 Aug 15;417(1):57-63. doi: 10.1016/j.virol.2011.05.005. Epub 2011 May 31.
Canine influenza virus (CIV) is an emerging pathogen that causes acute respiratory disease in dogs. To better understand the mechanism(s) responsible for the virulence of the virus, we conducted immunological, virological, clinical, and histopathological analyses in CIV-infected dogs. CIV replicated efficiently in the respiratory system of dogs and caused severe respiratory disease. Notably, the infection induced the marked elevation and sustained expression of chemokines that resulted in severe bronchointerstitial pneumonia with extensive neutrophil infiltration. In clinicopathological findings, CIV infection resulted in regenerative anemia, perhaps due to pulmonary hemorrhage. The observations indicate that active replication of CIV in the canine respiratory system results in intense inflammatory responses central to the pathogenesis of H3N2 CIV.
犬流感病毒（CIV）是一种新兴病原体，可导致犬急性呼吸道疾病。为了更好地了解病毒毒力的机制，我们对 CIV 感染犬进行了免疫学、病毒学、临床和组织病理学分析。CIV 在犬的呼吸系统中高效复制，引起严重的呼吸道疾病。值得注意的是，感染诱导了趋化因子的显著升高和持续表达，导致严重的细支气管炎伴广泛的中性粒细胞浸润。在临床病理发现中，CIV 感染导致再生性贫血，可能是由于肺出血。这些观察结果表明，CIV 在犬呼吸道中的活跃复制导致强烈的炎症反应，这是 H3N2 CIV 发病机制的核心。
