Nat Cell Biol. 2011 Jun;13(6):636-7. doi: 10.1038/ncb0611-636.
The primary cilium is proposed to restrain the level of canonical Wnt signalling, but it was unknown how the cilium achieves this. β-catenin, a component of the canonical Wnt signalling pathway, is now shown to be sequestered to the cilium by the Wnt signalling modulator Jouberin (Jbn) to restrain Wnt responses.
初级纤毛被认为可以限制经典 Wnt 信号通路的水平，但尚不清楚纤毛如何实现这一点。β-连环蛋白是经典 Wnt 信号通路的一个组成部分，现在表明它被 Wnt 信号调节剂 Jouberin (Jbn) 隔离到纤毛中，以抑制 Wnt 反应。
