Department of Psychology, Binghamton University (SUNY), Binghamton, NY 13902-6000, USA.
J Abnorm Child Psychol. 2011 Aug;39(6):783-90. doi: 10.1007/s10802-011-9526-2.
The goal of the current study was to examine environmental and genetic correlates of children's levels of behavioral inhibition (BI). Participants were 100 mother child pairs drawn from the community who were part of a larger study of the intergenerational transmission of depression. Results indicated that higher levels of maternal overprotection, as reported by the child, were associated with elevations in BI among children carrying two copies of the lower expressing 5-HTTLPR alleles (S or L(G)), but not among those carrying only one copy or those homozygous for the L(A) allele. In addition, this interaction was specific for the social component of BI, not the nonsocial component. This relation was maintained even after statistically controlling for children's and mother's psychopathology. Together, these findings add to emerging research demonstrating that G × E interactions predict variation in BI during childhood.
本研究旨在考察儿童行为抑制水平的环境和遗传相关性。参与者为 100 对来自社区的母子对，他们是一项关于抑郁代际传递的更大研究的一部分。结果表明，儿童报告的母亲过度保护程度越高，携带两个低表达 5-HTTLPR 等位基因（S 或 L(G)）的儿童的 BI 水平升高，但只携带一个拷贝或纯合 L(A)等位基因的儿童则不然。此外，这种相互作用是 BI 的社会成分的特异性，而不是非社会成分的特异性。即使在对儿童和母亲的精神病理学进行统计学控制后，这种关系仍然存在。这些发现与新兴研究一起表明，G×E 相互作用预测了儿童期 BI 的变化。
