Inserm U938, Paris F-75012, France.
Int J Biochem Cell Biol. 2011 Sep;43(9):1241-6. doi: 10.1016/j.biocel.2011.05.009. Epub 2011 May 23.
There is strong clinical evidence for the effectiveness of macrolides in the treatment of a number of chronic airway diseases through their immunomodulatory effects. Recently, new information has been released supporting the view that macrolides may also be beneficial in pathologic situations associated with altered repair of the alveolar structure, such as those observed in interstitial lung diseases and fibrosis. It is proposed that macrolides may contribute to lung regeneration through their actions on several components of the remodeling process. The present review provides new insights on the effects of macrolides on the regenerative response of alveolar epithelium to injury. It also discusses novel findings which suggest that macrolides may contribute to alveolar surfactant homeostasis.
有强有力的临床证据表明，大环内酯类药物通过其免疫调节作用，可有效治疗多种慢性气道疾病。最近，有新信息表明，大环内酯类药物在肺泡结构修复改变相关的病理情况下可能也有益，如间质性肺疾病和肺纤维化中观察到的情况。有观点认为，大环内酯类药物可能通过对重塑过程中的几个成分的作用，有助于肺再生。本综述就大环内酯类药物对肺泡上皮细胞损伤后再生反应的影响提供了新的见解。还讨论了新的发现，表明大环内酯类药物可能有助于肺泡表面活性物质的动态平衡。
