环境表观遗传跨代遗传与体细胞核有丝分裂稳定性
Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability.
机构信息
Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, USA.
出版信息
Epigenetics. 2011 Jul;6(7):838-42. doi: 10.4161/epi.6.7.16537. Epub 2011 Jul 1.
Abstract
The majority of environmental factors can not modify DNA sequence, but can influence the epigenome. The mitotic stability of the epigenome and ability of environmental epigenetics to influence phenotypic variation and disease, suggests environmental epigenetics will have a critical role in disease etiology and biological areas such as evolutionary biology. The current review presents the molecular basis of how environment can promote stable epigenomes and modified phenotypes, and distinguishes the difference between epigenetic transgenerational inheritance through the germ line versus somatic cell mitotic stability.
摘要
大多数环境因素不能改变 DNA 序列，但可以影响表观基因组。表观基因组的有丝分裂稳定性和环境表观遗传学影响表型变异和疾病的能力表明，环境表观遗传学将在疾病病因学和进化生物学等生物学领域发挥关键作用。本文综述了环境如何促进稳定的表观基因组和修饰表型的分子基础，并区分了通过生殖细胞和体细胞有丝分裂稳定性进行表观遗传跨代遗传的差异。
相似文献
1
Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability.环境表观遗传跨代遗传与体细胞核有丝分裂稳定性
Epigenetics. 2011 Jul;6(7):838-42. doi: 10.4161/epi.6.7.16537. Epub 2011 Jul 1.
2
Environmentally induced epigenetic transgenerational inheritance of phenotype and disease.环境诱导的表型和疾病的表观遗传跨代遗传。
Mol Cell Endocrinol. 2012 May 6;354(1-2):3-8. doi: 10.1016/j.mce.2011.10.004. Epub 2011 Oct 13.
3
Epigenetic transgenerational actions of environmental factors in disease etiology.环境因素在疾病病因学中的表观遗传跨代作用。
Trends Endocrinol Metab. 2010 Apr;21(4):214-22. doi: 10.1016/j.tem.2009.12.007. Epub 2010 Jan 14.
4
Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health.跨代遗传：父母的表观遗传和遗传信息如何影响后代的健康。
Hum Reprod Update. 2019 Sep 11;25(5):518-540. doi: 10.1093/humupd/dmz017.
5
Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution.代际稳定性的表观遗传跨代遗传促进了适应和进化。
Epigenetics. 2024 Dec;19(1):2380929. doi: 10.1080/15592294.2024.2380929. Epub 2024 Aug 5.
6
Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations.环境诱导的精子表观突变的表观遗传跨代遗传促进基因突变。
Epigenetics. 2015;10(8):762-71. doi: 10.1080/15592294.2015.1062207.
7
Transgenerational inheritance and its modulation by environmental cues.跨代遗传及其受环境线索的调节。
Curr Top Dev Biol. 2023;152:31-76. doi: 10.1016/bs.ctdb.2022.10.002. Epub 2022 Nov 14.
8
Epigenetic Transgenerational Inheritance of Altered Sperm Histone Retention Sites.表观遗传跨代传递改变的精子组蛋白保留位点。
Sci Rep. 2018 Mar 28;8(1):5308. doi: 10.1038/s41598-018-23612-y.
9
Nongenetic inheritance and transgenerational epigenetics.非遗传和跨代表观遗传学。
Trends Mol Med. 2015 Feb;21(2):134-44. doi: 10.1016/j.molmed.2014.12.004. Epub 2014 Dec 19.
10
The Role of DNA Methylation in Hypertension.DNA甲基化在高血压中的作用。
Adv Exp Med Biol. 2017;956:583-598. doi: 10.1007/5584_2016_80.
引用本文的文献
1
Air Pollution-Induced Neurotoxicity: The Relationship Between Air Pollution, Epigenetic Changes, and Neurological Disorders.空气污染诱发的神经毒性：空气污染、表观遗传变化与神经疾病之间的关系
Int J Mol Sci. 2025 Apr 5;26(7):3402. doi: 10.3390/ijms26073402.
2
Clearing the Air on Pollutant Disruptions of the Gut-Brain Axis: Developmental Exposure to Benzo[a]pyrene Disturbs Zebrafish Behavior and the Gut Microbiome in Adults and Subsequent Generations.澄清关于污染物对肠-脑轴干扰的问题：发育过程中接触苯并[a]芘会扰乱成年斑马鱼及其后代的行为和肠道微生物群。
Toxics. 2024 Dec 25;13(1):10. doi: 10.3390/toxics13010010.
3
Prenatal maternal stress in rats alters the epigenetic and transcriptomic landscape of the maternal-fetal interface across four generations.大鼠孕期母体应激会改变母胎界面的表观遗传和转录组格局，这种影响会延续四代。
Commun Biol. 2025 Jan 10;8(1):38. doi: 10.1038/s42003-024-07444-3.
4
Epigenetic regulation of cardiovascular diseases induced by behavioral and environmental risk factors: Mechanistic, diagnostic, and therapeutic insights.行为和环境危险因素所致心血管疾病的表观遗传调控：机制、诊断及治疗见解
FASEB Bioadv. 2024 Oct 1;6(11):477-502. doi: 10.1096/fba.2024-00080. eCollection 2024 Nov.
5
Epigenetic transgenerational inheritance of toxicant exposure-specific non-coding RNA in sperm.精子中特定毒物暴露的非编码RNA的表观遗传跨代遗传。
Environ Epigenet. 2024 Sep 4;10(1):dvae014. doi: 10.1093/eep/dvae014. eCollection 2024.
6
Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution.代际稳定性的表观遗传跨代遗传促进了适应和进化。
Epigenetics. 2024 Dec;19(1):2380929. doi: 10.1080/15592294.2024.2380929. Epub 2024 Aug 5.
7
Signatures of metabolic diseases on spermatogenesis and testicular metabolism.代谢性疾病对精子发生和睾丸代谢的影响特征。
Nat Rev Urol. 2024 Aug;21(8):477-494. doi: 10.1038/s41585-024-00866-y. Epub 2024 Mar 25.
8
Mixed Patterns of Intergenerational DNA Methylation Inheritance in Acropora.珊瑚中跨代 DNA 甲基化遗传的混合模式。
Mol Biol Evol. 2024 Feb 1;41(2). doi: 10.1093/molbev/msae008.
9
Advanced maternal age has negative multigenerational impacts during embryogenesis.高龄产妇在胚胎发育过程中会产生负面的多代影响。
Curr Res Insect Sci. 2023 Sep 13;4:100068. doi: 10.1016/j.cris.2023.100068. eCollection 2023.
10
Partners in diabetes epidemic: A global perspective.糖尿病流行的相关因素：全球视角
World J Diabetes. 2023 Oct 15;14(10):1463-1477. doi: 10.4239/wjd.v14.i10.1463.
本文引用的文献
1
Role of epigenetics in developmental biology and transgenerational inheritance.表观遗传学在发育生物学和跨代遗传中的作用。
Birth Defects Res C Embryo Today. 2011 Mar;93(1):51-5. doi: 10.1002/bdrc.20199.
2
Transgenerational inheritance of stress pathology.跨代应激病理学遗传。
Exp Neurol. 2012 Jan;233(1):95-101. doi: 10.1016/j.expneurol.2011.01.009. Epub 2011 Jan 31.
3
Epigenetic reprogramming in plant and animal development.动植物发育中的表观遗传重编程。
Science. 2010 Oct 29;330(6004):622-7. doi: 10.1126/science.1190614.
4
Metabolic disorders: Fathers' nutritional legacy.代谢紊乱：父亲的营养遗产。
Nature. 2010 Oct 21;467(7318):922-3. doi: 10.1038/467922a.
5
Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations.发育接触 TCDD 会降低生育能力，并在多个世代中对妊娠结局产生负面影响。
Reprod Toxicol. 2011 Apr;31(3):344-50. doi: 10.1016/j.reprotox.2010.10.003. Epub 2010 Oct 16.
6
Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome.代际间的外消旋体唑啉对精子表观基因组启动子区域的表观遗传作用。
PLoS One. 2010 Sep 30;5(9):e13100. doi: 10.1371/journal.pone.0013100.
7
Epigenetic transgenerational actions of environmental factors in disease etiology.环境因素在疾病病因学中的表观遗传跨代作用。
Trends Endocrinol Metab. 2010 Apr;21(4):214-22. doi: 10.1016/j.tem.2009.12.007. Epub 2010 Jan 14.
8
Impairment in protein expression profile of testicular steroid receptor coregulators in male rat offspring perinatally exposed to Bisphenol A.围产期暴露于双酚A的雄性大鼠后代睾丸类固醇受体共调节因子的蛋白质表达谱受损。
Life Sci. 2009 Jul 3;85(1-2):11-8. doi: 10.1016/j.lfs.2009.04.005. Epub 2009 Apr 18.
9
Chromatin remodeling during mitosis: a structure-based code?有丝分裂期间的染色质重塑：一种基于结构的编码？
Front Biosci (Landmark Ed). 2009 Jan 1;14(6):2017-27. doi: 10.2741/3360.
10
What is an epigenetic transgenerational phenotype? F3 or F2.什么是表观遗传跨代表型？F3代还是F2代？
Reprod Toxicol. 2008 Jan;25(1):2-6. doi: 10.1016/j.reprotox.2007.09.001. Epub 2007 Sep 11.
Zotero 插件