Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Shaanxi China.
Genet Mol Biol. 2009 Jan;32(1):32-6. doi: 10.1590/S1415-47572009005000002. Epub 2009 Jan 10.
hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils and other types of leukocytes in the affected skin. Catechol-O-methyltransferase (COMT) 158 polymorphism can reduce the activity of the COMT enzyme that may trigger defective differentiation of keratinocytes in psoriasis. Immunocytes can degrade and inactivate catecholamines via monamine oxidase (MAO) and COMT in the cells. We hypothesized that the COMT-158G > A polymorphism was associated with the risk of psoriasis vulgaris in Han Chinese people. In a hospital-based case-control study, 524 patients with psoriasis vulgaris and 549 psoriasis-free controls were studied. COMT-158 G > A polymorphism was genotyped using the PCR sequence-specific primer (PCR-SSP) technique. We found no statistically significant association between the COMT-158 allele A and the risk of psoriasis vulgaris (p = 0.739 adjusted OR = 1.03; 95% CI = 0.81-1.31). This suggests that the COMT-158 G > A polymorphism may not contribute to the etiology of psoriasis vulgaris in the Han Chinese population.
表皮角质形成细胞增生、血管增生和扩张，以及受影响皮肤中 T 淋巴细胞、中性粒细胞和其他类型白细胞的浸润。儿茶酚-O-甲基转移酶（COMT）158 多态性可降低 COMT 酶的活性，从而可能引发银屑病角质形成细胞的缺陷分化。免疫细胞可以通过单胺氧化酶（MAO）和细胞内的 COMT 降解和失活儿茶酚胺。我们假设 COMT-158G > A 多态性与汉族人寻常型银屑病的发病风险相关。在一项基于医院的病例对照研究中，研究了 524 例寻常型银屑病患者和 549 例无银屑病对照者。采用聚合酶链反应序列特异性引物（PCR-SSP）技术对 COMT-158G > A 多态性进行基因分型。我们发现 COMT-158 等位基因 A 与寻常型银屑病的发病风险之间没有统计学意义上的关联（调整后的 OR = 1.03，95%CI = 0.81-1.31，p = 0.739）。这表明 COMT-158G > A 多态性可能不会导致汉族人群寻常型银屑病的发病。
