Ferrándiz Carlos, Pujol Ramon M, García-Patos Vicente, Bordas Xavier, Smandía Joan A
Department of Dermatology, Hospital Germans Trias i Pujol, Barcelona, Spain.
J Am Acad Dermatol. 2002 Jun;46(6):867-73. doi: 10.1067/mjd.2002.120470.
The existence of 2 distinct forms of psoriasis related to age at onset has been postulated. However, precise data regarding the clinical and epidemiologic characteristics of psoriasis depending on the age at onset are still lacking.
The purpose of this study was to define the clinical and epidemiologic features of this disease in Spain and to compare patients with psoriasis of early and late onset.
An observational, analytic, cross-sectional, multicenter study was carried out. From January 1999 to November 1999, 179 participating dermatologists completed a questionnaire detailing the clinical and epidemiologic features of the first 10 consecutive patients with psoriasis seen in their clinical practice. The sample distribution was proportional to the Spanish population. Both statistical and descriptive analyses were performed.
Available data were obtained from 1774 patients. The onset of the disease before 30 years of age was significantly associated with a higher incidence of family history of psoriasis, a more severe and extensive cutaneous involvement, and greater psychosocial impact. Guttate psoriasis, nail involvement, evidence of precipitating factors, and a recurrent clinical course were more frequent in this group of patients. Patients with psoriasis of late onset had a less severe clinical course and a more continuous evolution. Palmoplantar pustulosis was more frequent in this group of patients. No significant relationship was detected between the age at onset and development of joint involvement.
Patients with early and late onset psoriasis often show different clinical and evolutionary features. From the analysis of our data, it seems that 2 different groups of patients with psoriasis related to age at onset can be defined.
据推测，银屑病存在两种与发病年龄相关的不同形式。然而，关于依据发病年龄划分的银屑病临床和流行病学特征的精确数据仍然匮乏。
本研究旨在明确西班牙该病的临床和流行病学特征，并比较早发型和晚发型银屑病患者。
开展了一项观察性、分析性、横断面、多中心研究。1999年1月至1999年11月期间，179名参与研究的皮肤科医生完成了一份问卷，详细记录了他们临床实践中连续诊治的前10例银屑病患者的临床和流行病学特征。样本分布与西班牙人口成比例。进行了统计分析和描述性分析。
获取了1774例患者的可用数据。30岁之前发病与银屑病家族史发病率较高、皮肤受累更严重和范围更广以及更大的社会心理影响显著相关。点滴状银屑病、指甲受累、诱发因素证据以及复发的临床病程在该组患者中更常见。晚发型银屑病患者的临床病程较轻且进展更持续。掌跖脓疱病在该组患者中更常见。未检测到发病年龄与关节受累发展之间存在显著关系。
早发型和晚发型银屑病患者通常表现出不同的临床和演变特征。从我们的数据分析来看，似乎可以定义两组与发病年龄相关的不同银屑病患者群体。
