Department of Endocrinology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Diabetologia. 2011 Sep;54(9):2404-8. doi: 10.1007/s00125-011-2208-3. Epub 2011 Jun 3.
AIMS/HYPOTHESIS: In diabetic children and adolescents, a history of severe hypoglycaemia (SH) has been associated with increased slow EEG activity and reduced cognition, possibly due to harmful effects of SH on the developing brain. In a group of type 1 diabetic patients with early exposure to SH, who had EEG abnormalities and reduced cognition in childhood, we have recently demonstrated that the reduced cognition may persist into adulthood. We have now assessed whether the reduced cognition was accompanied by lasting EEG abnormalities.
In 1992-1993, we studied EEG and cognition in 28 diabetic children and 28 matched controls. 16 years later, we re-investigated the same participants, with 96% participation rate. Diabetic participants were classified as with (n = 9) or without (n = 18) early SH, defined as episodes with convulsions or loss of consciousness by 10 years of age. For each EEG band (delta, theta, alpha and beta) and cerebral region (frontocentral, temporal, and parietooccipital), we calculated relative amplitudes and amplitude asymmetry. We also calculated occipital alpha mean frequency, alpha peak frequency at maximum amplitude, alpha peak width, and theta regional mean frequencies. We examined whether these EEG measures, relative to age- and sex-matched controls, differed between diabetic participants with and without early SH.
We found no association of early SH with any of the EEG measures.
CONCLUSIONS/INTERPRETATION: Childhood SH was not associated with EEG abnormalities in young type 1 diabetic adults. Our findings suggest that the reduced adulthood cognition associated with childhood exposure to SH is not accompanied by lasting EEG abnormalities.
目的/假设：在糖尿病儿童和青少年中，严重低血糖史（SH）与慢脑电活动增加和认知能力下降有关，这可能是由于 SH 对发育中的大脑产生了有害影响。在一组早期暴露于 SH 的 1 型糖尿病患者中，他们在儿童时期出现了 EEG 异常和认知能力下降，我们最近证明，这种认知能力下降可能会持续到成年期。我们现在评估了认知能力下降是否伴有持续的 EEG 异常。
1992-1993 年，我们研究了 28 名糖尿病儿童和 28 名匹配的对照组的 EEG 和认知能力。16 年后，我们以 96%的参与率重新调查了相同的参与者。糖尿病参与者被分为早期 SH 组（n = 9）或无早期 SH 组（n = 18），定义为 10 岁前出现癫痫发作或意识丧失的事件。对于每个 EEG 波段（delta、theta、alpha 和 beta）和脑区（额中央、颞叶和顶枕叶），我们计算了相对幅度和幅度不对称性。我们还计算了枕部 alpha 平均频率、最大幅度时的 alpha 峰值频率、alpha 峰值宽度和 theta 区域平均频率。我们检查了这些 EEG 测量值是否与无早期 SH 的糖尿病参与者存在差异，这些差异与年龄和性别匹配的对照组相关。
我们没有发现早期 SH 与任何 EEG 测量值之间存在关联。
结论/解释：童年时期的 SH 与年轻的 1 型糖尿病成年患者的 EEG 异常无关。我们的研究结果表明，与儿童时期暴露于 SH 相关的成年认知能力下降，并不伴有持续的 EEG 异常。
