Soltész G, Acsádi G
Department of Paediatrics, University of Pécs, Hungary.
Arch Dis Child. 1989 Jul;64(7):992-6. doi: 10.1136/adc.64.7.992.
Serial electroencephalographic recordings were made in 70 diabetic children and findings were related to age at electroencephalography and at diagnosis, duration of diabetes, daily insulin dose, long term metabolic control assessed by glycated haemoglobin A1 (HbA1) concentrations, and severe hypoglycaemic episodes. Abnormalities were found in 18 (26%) of diabetic children, and in only five (7%) of control subjects. There were no associations between electroencephalographic abnormalities and duration of diabetes, daily insulin dose, or HbA1 concentration. Diabetic children with electroencephalographic abnormalities were younger, had an earlier onset of diabetes and 21/34 (62%) of them had previously severe attacks of hypoglycaemia, whereas abnormalities were found in only 13/43 (30%) of diabetic children who had not had severe hypoglycaemia. All diabetic children with hypoglycaemic convulsions had permanent electroencephalographic abnormalities. The degree of metabolic control had no effect on the electroencephalographic findings during the early years of diabetes, but previous severe hypoglycaemia, young age, and early onset seem to be important risk factors for electroencephalographic abnormalities.
对70名糖尿病儿童进行了系列脑电图记录，并将结果与脑电图检查时及诊断时的年龄、糖尿病病程、每日胰岛素剂量、通过糖化血红蛋白A1（HbA1）浓度评估的长期代谢控制情况以及严重低血糖发作情况相关联。在18名（26%）糖尿病儿童中发现了异常，而在仅5名（7%）对照受试者中发现异常。脑电图异常与糖尿病病程、每日胰岛素剂量或HbA1浓度之间无关联。有脑电图异常的糖尿病儿童年龄较小，糖尿病发病较早，其中21/34（62%）曾有严重低血糖发作，而在未发生严重低血糖的糖尿病儿童中，只有13/43（30%）发现异常。所有有低血糖惊厥的糖尿病儿童都有永久性脑电图异常。在糖尿病早期，代谢控制程度对脑电图结果无影响，但既往严重低血糖、年幼和发病早似乎是脑电图异常的重要危险因素。
