Furge Laura Lowe, Guengerich F Peter
Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan 49006-3295.
Biochem Mol Biol Educ. 2006 Mar;34(2):66-74. doi: 10.1002/bmb.2006.49403402066.
Cytochrome P450 (P450) enzymes include a family of related enzymes that are involved in metabolism of vitamins, steroids, fatty acids, and other chemicals. This review presents a brief historical overview of the discovery and characterization of P450 enzymes extending from intermediary metabolism to the fields of drug metabolism and toxicology. Introductions to P450 enzyme structure and function are also presented. The goals of this review are to 1) provide an introduction to a few of the many aspects of P450 research relating to humans, 2) introduce additional ways of thinking about metabolism, 3) provide some basic examples of P450 enzymology, and 4) provide applications to topics widely taught in undergraduate courses in biochemistry.
细胞色素P450（P450）酶包括一族相关的酶，它们参与维生素、类固醇、脂肪酸及其他化学物质的代谢。本综述简要介绍了P450酶从中间代谢到药物代谢和毒理学领域的发现及特性的历史概况。文中还介绍了P450酶的结构和功能。本综述的目的是：1）介绍P450研究中与人类相关的众多方面中的一些内容；2）引入关于代谢的其他思考方式；3）提供一些P450酶学的基本实例；4）提供在本科生物化学课程中广泛讲授的主题的应用。
