Department of Psychology, University of Missouri-St Louis, Behavioral Neuroscience, St Louis, MO 63121, USA.
Arch Clin Neuropsychol. 2011 Aug;26(5):454-60. doi: 10.1093/arclin/acr017. Epub 2011 Jun 4.
The Montreal Cognitive Assessment (MoCA) screen was developed as a brief instrument to identify mild cognitive impairment and dementia among older individuals. To date, limited information is available regarding the neuroimaging signatures associated with performance on the scale, or the relationship between the MoCA and more comprehensive cognitive screening measures. The present study examined performances on the MoCA among 111 non-clinical older adults (ages 51-85) enrolled in a prospective study of cognitive aging. Participants were administered the MoCA, Mini-Mental State Exam (MMSE), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). A subset of participants (N = 69) underwent structural 3 T magnetic resonance imaging (MRI) to define the volumes of total frontal gray matter, total hippocampus, T2-weighted subcortical hyperintensities (SH), and total brain volume. The results revealed significant correlations between the total score on the MoCA and total score on the RBANS and MMSE, though the strength of the correlations was more robust between the MoCA and the RBANS. Modest correlations between individual subscales of the MoCA and neuroimaging variables were evident, but no patterns of shared variance emerged between the MoCA total score and neuroimaging indices. In contrast, total brain volume correlated significantly with total score on the RBANS. These results suggest that additional studies are needed to define the significance of MoCA scores relative to brain integrity among an older population.
蒙特利尔认知评估（MoCA）测试是一种用于识别老年人轻度认知障碍和痴呆的简捷工具。迄今为止，关于与该量表测试成绩相关的神经影像学特征，或者 MoCA 与更全面的认知筛查测试之间的关系，相关信息非常有限。本研究对 111 名参加认知老化前瞻性研究的非临床老年人（年龄 51-85 岁）的 MoCA 测试表现进行了研究。参与者接受了 MoCA、简易精神状态检查（MMSE）和神经心理学评估的可重复电池（RBANS）的测试。部分参与者（N=69）接受了 3T 磁共振成像（MRI）检查，以确定总额状回灰质、总海马体、T2 加权皮质下高信号（SH）和总脑容量的体积。结果显示，MoCA 总分与 RBANS 和 MMSE 总分之间存在显著相关性，但 MoCA 与 RBANS 之间的相关性更强。MoCA 各分量表与神经影像学变量之间存在适度的相关性，但 MoCA 总分与神经影像学指标之间没有出现共同方差的模式。相比之下，总脑容量与 RBANS 总分显著相关。这些结果表明，需要进一步的研究来确定 MoCA 评分在老年人的大脑完整性方面的意义。
