简易精神状态检查表与蒙特利尔认知评估量表在识别帕金森病认知缺陷方面的比较。

A comparison of the mini mental state exam to the Montreal cognitive assessment in identifying cognitive deficits in Parkinson's disease.

作者信息

Zadikoff Cindy, Fox Susan H, Tang-Wai David F, Thomsen Teri, de Bie Rob M A, Wadia Pettarusup, Miyasaki Janis, Duff-Canning Sarah, Lang Anthony E, Marras Connie

机构信息

Department of Neurology, Northwestern University, Parkinson's Disease and Movement Disorders Center, Chicago, Illinois, USA.

出版信息

Mov Disord. 2008 Jan 30;23(2):297-9. doi: 10.1002/mds.21837.

DOI:10.1002/mds.21837

PMID:18044697

Abstract

Dementia is an important and increasingly recognized problem in Parkinson's disease (PD). The mini-mental state examination (MMSE) often fails to detect early cognitive decline. The Montreal cognitive assessment (MoCA) is a brief tool developed to detect mild cognitive impairment that assesses a broader range of domains frequently affected in PD. The scores on the MMSE and the MoCA were compared in 88 patients with PD. A pronounced ceiling effect was observed with the MMSE but not with the MoCA. The range and standard deviation of scores was larger with the MoCA(7-30, 4.26) than with the MMSE(16-30, 2.55). The percentage of subjects scoring below a cutoff of 26/30 (used by others to detect mild cognitive impairment) was higher on the MoCA (32%) than on the MMSE (11%) (P < 0.000002). Compared to the MMSE, the MoCA may be a more sensitive tool to identify early cognitive impairment in PD.

摘要

痴呆是帕金森病（PD）中一个重要且日益受到重视的问题。简易精神状态检查表（MMSE）常常无法检测出早期认知衰退。蒙特利尔认知评估量表（MoCA）是一种为检测轻度认知障碍而开发的简短工具，它评估了帕金森病中经常受到影响的更广泛领域。对88例帕金森病患者的MMSE和MoCA得分进行了比较。MMSE观察到明显的天花板效应，而MoCA则未观察到。MoCA得分的范围和标准差（7 - 30，4.26）比MMSE（16 - 30，2.55）更大。MoCA上得分低于26/30临界值（其他人用于检测轻度认知障碍）的受试者百分比（32%）高于MMSE（11%）（P < 0.000002）。与MMSE相比，MoCA可能是识别帕金森病早期认知障碍更敏感的工具。