Erdoğan Mutlu, Öktem Bülent, Kalaycıoğlu Hamit, Yavaş Seydi, Mukhopadhyay Pranab K, Eken Koray, Ozgören Kıvanç, Aykaç Yaşar, Tazebay Uygar H, Ilday F Ömer
Materials Science and Nanotechnology Graduate Program, Bilkent University, Ankara 06800, Turkey.
Opt Express. 2011 May 23;19(11):10986-96. doi: 10.1364/OE.19.010986.
We propose and demonstrate the use of short pulsed fiber lasers in surface texturing using MHz-repetition-rate, microjoule- and sub-microjoule-energy pulses. Texturing of titanium-based (Ti6Al4V) dental implant surfaces is achieved using femtosecond, picosecond and (for comparison) nanosecond pulses with the aim of controlling attachment of human cells onto the surface. Femtosecond and picosecond pulses yield similar results in the creation of micron-scale textures with greatly reduced or no thermal heat effects, whereas nanosecond pulses result in strong thermal effects. Various surface textures are created with excellent uniformity and repeatability on a desired portion of the surface. The effects of the surface texturing on the attachment and proliferation of cells are characterized under cell culture conditions. Our data indicate that picosecond-pulsed laser modification can be utilized effectively in low-cost laser surface engineering of medical implants, where different areas on the surface can be made cell-attachment friendly or hostile through the use of different patterns.
我们提出并展示了使用重复频率为兆赫兹、能量为微焦耳和亚微焦耳脉冲的短脉冲光纤激光器进行表面纹理化。使用飞秒、皮秒（作为对比）和纳秒脉冲对钛基（Ti6Al4V）牙科植入物表面进行纹理化处理，目的是控制人类细胞在该表面的附着。飞秒和皮秒脉冲在产生微米级纹理方面产生相似的结果，热效应大大降低或不存在，而纳秒脉冲则会产生强烈的热效应。在表面的期望部分以优异的均匀性和可重复性创建了各种表面纹理。在细胞培养条件下对表面纹理化对细胞附着和增殖的影响进行了表征。我们的数据表明，皮秒脉冲激光改性可有效地用于医疗植入物的低成本激光表面工程，通过使用不同的图案，可以使表面的不同区域对细胞附着友好或具有排斥性。
