Soffer D, Resnick-Roguel N, Eldor A, Kotler M
Department of Pathology, Hebrew University Hadassah Medical School, Jerusalem, Israel.
Cancer Res. 1990 Aug 1;50(15):4787-93.
The morphological features of a spontaneous, multifocal vascular neoplasm of chickens are described. Histologically, the tumor was characterized by areas consisting of freely anastomosing vascular channels with prominent papillary appearance and lined by bland-looking endothelial cells, which alternate with areas resembling cavernous hemangioma. Occasionally solid areas composed of plump, pleomorphic cells were also present. Although there was no clear evidence for metastatic spread, some tumors were obviously invasive. Electron microscopy and immunohistochemistry confirmed the endothelial nature of neoplastic cells, demonstrating in particular pinocytic vesicles, well developed junctional complexes, fragmented basal lamina, occasional Weibel-Palade bodies, and patchy factor VIII-related antigen immunoreactivity. The overall appearance of the tumor was that of a cavernous hemangioma with prominent papillary endothelial hyperplasia. Previously we have shown that the tumor was induced by a newly isolated strain of avian hemangioma retrovirus and in this study we demonstrated typical type C retrovirus particles in the tumor by electron microscopy. It is suggested that this retrovirus-induced avian tumor may serve as a useful model for the study of transformed endothelia and other vascular tumorigenesis.
本文描述了鸡自发性多灶性血管肿瘤的形态学特征。组织学上，肿瘤的特征是由自由吻合的血管通道组成的区域，具有明显的乳头状外观，内衬外观温和的内皮细胞，这些区域与类似海绵状血管瘤的区域交替出现。偶尔也会出现由丰满、多形性细胞组成的实性区域。虽然没有明确的转移扩散证据，但一些肿瘤具有明显的侵袭性。电子显微镜和免疫组织化学证实了肿瘤细胞的内皮性质，特别显示了吞饮小泡、发育良好的连接复合体、破碎的基底膜、偶尔出现的Weibel-Palade小体以及散在的因子VIII相关抗原免疫反应性。肿瘤的总体外观是具有明显乳头状内皮增生的海绵状血管瘤。此前我们已表明该肿瘤由新分离的禽血管瘤逆转录病毒株诱导，在本研究中，我们通过电子显微镜在肿瘤中发现了典型的C型逆转录病毒颗粒。有人提出，这种逆转录病毒诱导的禽肿瘤可能作为研究转化内皮细胞和其他血管肿瘤发生的有用模型。
