State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University, Tianjin, China.
J Org Chem. 2011 Jul 15;76(14):5838-45. doi: 10.1021/jo200557b. Epub 2011 Jun 16.
A highly diastereo- and enantioselective asymmetric allylic alkylation reaction with respect to prochiral 3-substituted benzofuran-2(3H)-ones and MBH carbonate by a chiral biscinchona alkaloid catalyst was investigated. The corresponding adducts, containing a quaternary center at the C3-position of the benzofuran-2(3H)-one as well as a vicinal tertiary center, were generally obtained in high yields (up to 97%) with very good diastereo- (up to 98:2 dr) and enantioselectivities (up to 95% ee).
研究了手性金鸡纳生物碱催化剂对前手性 3-取代苯并呋喃-2(3H)-酮和 MBH 碳酸盐的高非对映选择性和对映选择性不对称烯丙基烷基化反应。相应的加合物，在苯并呋喃-2(3H)-酮的 C3-位含有季碳原子以及相邻的叔中心，通常以高产率（高达 97%）获得，具有非常好的非对映选择性（高达 98:2 dr）和对映选择性（高达 95%ee）。
