Clere Nicolas, Faure Sébastien, Martinez Maria Carmen, Andriantsitohaina Ramaroson
INSERM UMR U694, Université d'Angers, Angers, France.
Cardiovasc Hematol Agents Med Chem. 2011 Apr 1;9(2):62-77. doi: 10.2174/187152511796196498.
High dietary intake of fruits and vegetables is consistently associated with a reduced risk of common human cancers. The specific mechanisms of action of most phytochemicals in cancer prevention are not yet clear but appear to be varied. One class of compounds currently under investigation is flavonoids, a large group of molecules with similar structure. Although their bioavailability is discussed, numerous in vitro and animal model data suggest that flavonoids modulate important cellular and molecular mechanisms related to carcinogenesis, a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor cells. Epidemiological studies confirmed that, among many flavonoids, apigenin, epigallocatechin gallate, delphinidin and genistein appear to be beneficial compounds in various stages of carcinogenesis. Therefore, according to in vitro and in vivo studies, this review attempts to increase our understanding about the preventive and therapeutic effects of these compounds to facilitate extrapolation of results from animal studies to human situations.
高水果和蔬菜摄入量一直与降低人类常见癌症风险相关。大多数植物化学物质在癌症预防中的具体作用机制尚不清楚，但似乎各不相同。目前正在研究的一类化合物是黄酮类化合物，这是一大类结构相似的分子。尽管人们讨论了它们的生物利用度，但大量的体外和动物模型数据表明，黄酮类化合物可调节与致癌作用相关的重要细胞和分子机制，致癌作用是一个多步骤过程，涉及肿瘤细胞的转化、存活、增殖、侵袭、血管生成和转移。流行病学研究证实，在众多黄酮类化合物中，芹菜素、表没食子儿茶素没食子酸酯、飞燕草素和染料木黄酮似乎是致癌作用各个阶段的有益化合物。因此，根据体外和体内研究，本综述试图增进我们对这些化合物预防和治疗作用的理解，以促进将动物研究结果外推至人类情况。
