人乳头瘤病毒16型（HPV-16）抗体的低亲和力与低风险HPV类型流行率增加相关，但与高风险HPV类型流行率增加无关。

Low avidity of human papillomavirus (HPV) type 16 antibodies is associated with increased risk of low-risk but not high-risk HPV type prevalence.

作者信息

Namujju Proscovia B, Hedman Lea, Hedman Klaus, Banura Cecily, Mbidde Edward K, Kizito Dennison, Byaruhanga Romano N, Muwanga Moses, Kirnbauer Reinhard, Surcel Heljä-Marja, Lehtinen Matti

机构信息

National Institute for Health and Welfare, Oulu, Finland.

出版信息

BMC Res Notes. 2011 Jun 6;4:170. doi: 10.1186/1756-0500-4-170.

DOI:10.1186/1756-0500-4-170

PMID:21645376

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3118998/

Abstract

BACKGROUND

Low avidity of antibodies against viral, bacterial and parasitic agents has been used for differential diagnosis of acute versus recent/past infections. The low-avidity antibodies may however, persist for a longer period in some individuals.

FINDINGS

We studied the association of human papillomavirus (HPV) type 16 antibody avidity with seroprevalence to HPV types 6/11/18/31/33/45. Antibody avidity was analysed for 365 HPV16 seropositive pregnant Finnish and Ugandan women using a modified ELISA.Low avidity of HPV16 antibodies was found in 15% of Finnish and 26% of Ugandan women. Ugandan women with low-avidity HPV16 antibodies had an increased risk estimate for HPV6/11 (odds ratio, OR 2.9; 95%CI 1.01-8.4) seropositivity but not to high-risk HPV types 18/31/33/45.

CONCLUSION

Association of the low avidity HPV16 antibody "phenotype" with possible susceptibility to infections with other HPV types warrants investigation.

摘要

背景

针对病毒、细菌和寄生虫病原体的低亲和力抗体已被用于急性感染与近期/既往感染的鉴别诊断。然而，低亲和力抗体在某些个体中可能会持续更长时间。

研究结果

我们研究了16型人乳头瘤病毒（HPV）抗体亲和力与6/11/18/31/33/45型HPV血清阳性率之间的关联。使用改良的酶联免疫吸附测定法（ELISA）对365名芬兰和乌干达HPV16血清阳性孕妇的抗体亲和力进行了分析。在15%的芬兰妇女和26%的乌干达妇女中发现了低亲和力的HPV16抗体。HPV16抗体亲和力低的乌干达妇女HPV6/11血清阳性的风险估计增加（优势比，OR 2.9；95%置信区间1.01-8.4），但对18/31/33/45型高危HPV则不然。