Palmroth Johanna, Namujju Proscovia, Simen-Kapeu Aline, Kataja Vesa, Surcel Heljä-Marja, Tuppurainen Marjo, Yliskoski Merja, Syrjänen Kari, Lehtinen Matti
Department of Obstetrics and Gynaecology, Kuopio University Hospital, Kuopio, Finland.
Scand J Infect Dis. 2010 May;42(5):379-84. doi: 10.3109/00365540903501608.
The risk of seroconversion for multiple human papillomavirus (HPV) types over time was studied in a cohort of 532 women with cervical HPV infection, prospectively followed-up for >10 y. Of the women who were HPV-antibody positive for at least 1 of the HPV types (6, 11 (low risk, lr), 16, 18, 31, 33, and 45 (high risk, hr)) at baseline, 73-98% seroconverted for 1 or more HPV types over time. Baseline lrHPV-seropositive women had 2.3-fold risk (95% confidence interval (CI) 1.1-4.7) for hrHPV seroconversion, but the opposite was not the case. Cross-protection by the natural HPV16 or HPV18 infection against other types of the HPV species A9 or A7 was not seen. These data suggest that protection against other HPV genotypes (as indicated by the lack of seroconversion) may not be provided by humoral HPV antibodies derived from a natural infection. Instead, these unvaccinated, HPV-antibody-positive women continue to be susceptible to infections by the other HPV genotypes over time.
在一项对532名宫颈人乳头瘤病毒（HPV）感染女性的队列研究中，对她们进行了超过10年的前瞻性随访，以研究多种HPV类型随时间发生血清转化的风险。在基线时，至少对一种HPV类型（6、11（低风险，lr）、16、18、31、33和45（高风险，hr））呈HPV抗体阳性的女性中，73%至98%的人随时间发生了一种或多种HPV类型的血清转化。基线时lrHPV血清阳性的女性发生hrHPV血清转化的风险为2.3倍（95%置信区间（CI）1.1 - 4.7），但反之则不然。未观察到自然感染HPV16或HPV18对HPV物种A9或A7的其他类型有交叉保护作用。这些数据表明，自然感染产生的体液HPV抗体可能无法提供针对其他HPV基因型的保护（表现为缺乏血清转化）。相反，这些未接种疫苗、HPV抗体阳性的女性随着时间的推移仍易受其他HPV基因型的感染。
