Department of Environmental Biology and Fisheries, Adekunle Ajasin University, Akungba-Akoko, Nigeria.
Parasitol Res. 2012 Jan;110(1):219-26. doi: 10.1007/s00436-011-2472-7. Epub 2011 Jun 7.
Methanolic extracts of Anogeissus leiocarpus has been considered locally to have the same antimalarial activities as artemisinin derivatives. This work studied the in vivo antiplasmodial activity of methanolic extracts of A. leiocarpus and its effect on oxidative stress and lipid profile in mice infected with Plasmodium bergheii. Mice used for this study were divided into five groups; four of the groups were infected with P. bergheii. The first group was not infected with the parasite. The second group was infected with parasite but not treated with antimalarial drugs (negative control). The third group was infected and treated with artesunat at 5 mg/kg body weight (positive control), while the fourth and fifth groups were infected and treated with 100 and 200 mg/kg body weight of extract of stem bark of A. leiocarpus, respectively. The rate of parasite clearance was higher in the group treated with 200 mg/kg body weight of extract of A. leiocarpus when compared with the groups treated with artesunat. Malondialdehyde (MDA) level was significantly higher (P < 0.05) in the serum of negative control as compared with other groups which have received treatment. MDA level was moderately higher in the liver homogenates of infected mice treated with artesunat than in other groups. There were significant increases (P < 0.05) in the levels of serum and liver superoxide dismutase of infected mice treated with 200 mg/kg body weight of A. leiocarpus when compared with other groups. Serum low density lipoprotein, total triglyceride, and total cholesterol were moderately higher in the group treated with artesunat than other groups, while high density lipoprotein (HDL) level was higher in the two groups treated with A. leiocarpus as compared with the group treated with artesunat. This study shows that the methanolic extract of A. leiocarpus has high antimalarial activities, high antioxidant property, and capable of boosting HDL level in malaria-infected organisms.
麻风树的甲醇提取物被认为具有与青蒿素衍生物相同的抗疟活性。本研究研究了麻风树甲醇提取物对感染伯氏疟原虫的小鼠的体内抗疟活性及其对氧化应激和脂质谱的影响。用于本研究的小鼠分为五组; 其中四组感染了 P. bergheii。第一组未感染寄生虫。第二组感染了寄生虫但未用抗疟药物治疗（阴性对照）。第三组用 5mg/kg 体重的青蒿琥酯治疗（阳性对照），第四组和第五组分别用 100 和 200mg/kg 体重的麻风树茎皮提取物感染和治疗。与用青蒿琥酯治疗的组相比，用 200mg/kg 体重的麻风树提取物治疗的组寄生虫清除率更高。与其他接受治疗的组相比，阴性对照组血清中的丙二醛（MDA）水平显著升高（P < 0.05）。感染小鼠肝匀浆中用青蒿琥酯治疗的 MDA 水平略高于其他组。与其他组相比，用 200mg/kg 体重的麻风树提取物治疗的感染小鼠血清和肝中超氧化物歧化酶（SOD）水平显著升高（P < 0.05）。与其他组相比，用青蒿琥酯治疗的组血清和肝中低密度脂蛋白（LDL）、总三酰甘油和总胆固醇水平略高，而用麻风树治疗的两组高密度脂蛋白（HDL）水平高于用青蒿琥酯治疗的组。本研究表明，麻风树的甲醇提取物具有较高的抗疟活性、较高的抗氧化能力，并能提高感染疟原虫生物的 HDL 水平。
