Trindade J C, Rangel M C, Ross J H, Jojima K, Stowe N T, Kay R, Pontes J E
Department of Urology, Cleveland Clinic Foundation, Ohio.
J Urol. 1990 Aug;144(2 Pt 2):418-21; discussion 422. doi: 10.1016/s0022-5347(17)39478-8.
It has been reported that unilateral nephrectomy causes acceleration of the growth of a Wistar/Furth rat Wilms tumor. We studied this phenomenon in parabiotic rats by measuring tumor growth after either sham nephrectomy, or excision of 1, 2 or 3 kidneys. We observed no stimulation of tumor growth in the experimental groups. Renal function was significantly decreased after removal of 2 or 3 kidneys. Serum creatinine levels were significantly different between right and left members of parabiotic pairs in these 2 groups. The effect of unilateral and bilateral nephrectomy on tumor growth in single rats also was examined. In these rats progressive increases in tumor growth were observed after unilateral and bilateral nephrectomy. Our inability to demonstrate a tumor-stimulating factor in the parabiotic model may be due partly to incomplete sharing of humoral factors between parabionts. Serum transfer studies in vitro may prove more fruitful in demonstrating such a factor.
据报道，单侧肾切除会加速Wistar/Furth大鼠肾母细胞瘤的生长。我们通过测量假肾切除、切除1个、2个或3个肾脏后肿瘤的生长情况，在联体大鼠中研究了这一现象。我们在实验组中未观察到肿瘤生长受到刺激。切除2个或3个肾脏后，肾功能显著下降。在这两组中，联体对的右侧和左侧成员之间血清肌酐水平存在显著差异。我们还研究了单侧和双侧肾切除对单只大鼠肿瘤生长的影响。在这些大鼠中，单侧和双侧肾切除后观察到肿瘤生长逐渐增加。我们无法在联体模型中证明存在肿瘤刺激因子，这可能部分是由于联体之间体液因子的不完全共享。体外血清转移研究可能在证明这种因子方面更有成效。
