Tritsch G L, Williams P D, Sufrin G, Murphy G P
Urology. 1985 May;25(5):511-4. doi: 10.1016/0090-4295(85)90463-7.
Contralateral kidneys, removed forty-eight hours after unilateral nephrectomy, contain renotropic growth factors with different effects on normal kidney and Wistar/Furth rat Wilms tumor. Receptors on tumor cells bind factors which, when eluted followed by in vivo bioassay, stimulate the growth of Wilms tumor. Receptors on normal kidney cortex cells bind factors which, when eluted, produce kidney hypotrophy in nontumor-bearing rats.
在单侧肾切除术后48小时切除的对侧肾脏中，含有对正常肾脏和Wistar/Furth大鼠肾母细胞瘤有不同作用的促肾生长因子。肿瘤细胞上的受体结合这些因子，洗脱后进行体内生物测定时，这些因子会刺激肾母细胞瘤的生长。正常肾皮质细胞上的受体结合这些因子，洗脱后，这些因子会在未荷瘤大鼠中导致肾萎缩。
