Department of Cardiac Surgery, University Medical Centre, Heidelberg, Germany.
Can J Cardiol. 2011 Jul-Aug;27(4):523.e25-9. doi: 10.1016/j.cjca.2010.12.063. Epub 2011 Jun 8.
Increased pulmonary blood flow in patients with left-to-right shunt has been shown to be associated with alterations in prostacyclin-synthesis. There are limited data with respect to the plasma cAMP in patients with elevated pulmonary artery pressure due to left-to-right shunt. We hypothesized that plasma cAMP might be influenced by pulmonary blood flow or pressure in patients with left-to-right shunt.
Plasma cAMP from venous blood was measured in 122 healthy controls aged 8.3 (0.2 - 14.9) years (median [range]) and in 130 patients with left-to-right shunt aged 1.4 (0.1 - 19.1) years by radioimmunoassay.
Plasma cAMP in controls and in patients was similar and decreased with age. Healthy infants (n = 42) showed higher plasma cAMP (46 [27-112] nmol/l) than children > 6 years of age (n = 40, 39 [19-73] nmol/l; P < 0.001).
These values should be taken into consideration when reporting plasma values for cAMP in patients with congenital heart disease. The values for healthy children obtained in this study should allow a better interpretation of plasma cAMP levels in various disease conditions such as chronic renal failure, liver chirrhosis, hyperthyreosis, or children with intellectual disability.
已证实左向右分流患者肺血流量增加与前列环素合成改变有关。由于左向右分流导致肺动脉压升高的患者的血浆环磷酸腺苷（cAMP）的数据有限。我们假设肺血流量或压力可能会影响左向右分流患者的血浆 cAMP。
采用放射免疫法测定 122 名年龄为 8.3（0.2-14.9）岁（中位数[范围]）的健康对照者和 130 名左向右分流患者的静脉血中血浆 cAMP。
对照组和患者的血浆 cAMP 相似，并随年龄而降低。健康婴儿（n=42）的血浆 cAMP 较高（46[27-112]nmol/L），而>6 岁的儿童（n=40，39[19-73]nmol/L；P<0.001）。
在报告先天性心脏病患者的血浆 cAMP 值时应考虑这些值。本研究中获得的健康儿童值应允许更好地解释慢性肾衰竭、肝硬化、甲状腺功能亢进或智力残疾等各种疾病条件下的血浆 cAMP 水平。
