阿塞那平在治疗与双相 I 障碍相关的躁狂或混合状态中的作用。
The role of asenapine in the treatment of manic or mixed states associated with bipolar I disorder.
机构信息
Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy;
出版信息
Neuropsychiatr Dis Treat. 2011;7:259-65. doi: 10.2147/NDT.S17259. Epub 2011 May 6.
BACKGROUND
Bipolar disorders (BD) are of particular public health significance as they are prevalent, severe and disabling, and often associated with elevated risks of premature mortality. The aim of this concise overview is to investigate the role of asenapine in the treatment of manic and mixed states associated with BD type 1 disorder.
METHOD
MedLine, Excerpta Medica and PsycINFO searches were performed to identify papers in English published over the past 7 years. Search terms were "asenapine", "manic" OR "mixed states", "bipolar I disorder". Subjects included in this study suffered from BD type 1 disorder.
RESULTS
To date, only four studies of asenapine for the treatment of manic or mixed episodes associated with BD type 1 have been published.
CONCLUSION
Research indicates that asenapine is generally well-tolerated, and that asenapine is efficacious and not inferior to olanzapine in the treatment of mixed or manic episodes associated with BD type 1 in the short-term and long-term.
背景
双相情感障碍（BD）具有重要的公共卫生意义，因为它普遍存在、严重且致残，并且常与过早死亡的风险升高相关。本简明综述的目的在于研究阿塞那平在治疗与 1 型 BD 相关的躁狂和混合状态中的作用。
方法
检索了过去 7 年发表的英文文献，使用的数据库包括 MedLine、Excerpta Medica 和 PsycINFO。检索词为“asenapine”、“躁狂”或“混合状态”、“1 型双相情感障碍”。本研究纳入的受试者患有 1 型 BD。
结果
迄今为止，仅有 4 项关于阿塞那平治疗与 1 型 BD 相关的躁狂或混合发作的研究发表。
结论
研究表明，阿塞那平总体上具有良好的耐受性，且在短期和长期内，阿塞那平治疗与 1 型 BD 相关的混合或躁狂发作的疗效不劣于奥氮平。
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