Dragunow M, Faull R L
Department of Pharmacology, School of Medicine, University of Auckland, New Zealand.
Neurosci Lett. 1990 May 31;113(2):144-50. doi: 10.1016/0304-3940(90)90294-j.
MK801, a non-competitive NMDA receptor antagonist, leads to a dramatic induction of c-fos-like protein in neurons in deep layers of the neocortex, in dorsal and ventral midline thalamic nuclei and in neurons in the central grey of rat brain. This induction of c-fos by MK801 is dose- and time-dependent occurring within 2 h and dissipating by 24 h after injection (0.5-8.0mg/kg, i.p.). The mechanism of this paradoxical induction of c-fos by MK801 is unclear, however the pattern of induction appears to follow the distribution of the antagonist-preferring NMDA receptor site.
MK801是一种非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，可导致大鼠大脑新皮质深层神经元、背侧和腹侧中线丘脑核以及中脑导水管周围灰质神经元中c-fos样蛋白的显著诱导。MK801对c-fos的这种诱导具有剂量和时间依赖性，在注射后2小时内出现（腹腔注射0.5 - 8.0mg/kg），并在24小时后消失。然而，MK801对c-fos这种矛盾诱导的机制尚不清楚，但其诱导模式似乎遵循拮抗剂偏好的NMDA受体位点的分布。
