Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Stem Cell Rev Rep. 2012 Mar;8(1):128-36. doi: 10.1007/s12015-011-9285-z.
Induced pluripotent stem (iPS) cells can be derived from somatic cells. Four key factors are required in this process including Oct4, Sox2, Klf4 and c-Myc. Ectopic expression of these four factors in somatic cells leads to reprogramming. Recent studies show that the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex plays critical roles in reprogramming of somatic cells and maintaining the pluripotency of stem cells. The possible mechanism is that SWI/SNF enhances the binding activity of reprogramming factors to pluripotent gene promoters and thus increases the reprogramming efficiency. Here, we review these recent advances and discuss how SWI/SNF plays a role in reprogramming. Understanding this mechanism will be helpful to find out the detail of reprogramming, which may provide a new therapy in medical science by generating patient-specific pluripotent stem cells.
诱导多能干细胞（iPS 细胞）可由体细胞诱导产生。在这个过程中需要四种关键因子，包括 Oct4、Sox2、Klf4 和 c-Myc。在体细胞中异位表达这四种因子可导致重编程。最近的研究表明，SWItch/Sucrose NonFermentable（SWI/SNF）染色质重塑复合物在体细胞重编程和维持干细胞多能性中发挥着关键作用。其可能的机制是 SWI/SNF 增强了重编程因子与多能基因启动子的结合活性，从而提高了重编程效率。本文综述了这些最新进展，并讨论了 SWI/SNF 在重编程中的作用。了解这一机制有助于揭示重编程的细节，这可能通过生成患者特异性多能干细胞为医学提供新的治疗方法。
