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碳纳米管对树突状细胞的直接作用导致肺部暴露后免疫抑制。

Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.

机构信息

Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.

出版信息

ACS Nano. 2011 Jul 26;5(7):5755-62. doi: 10.1021/nn2014479. Epub 2011 Jun 15.

DOI:10.1021/nn2014479
PMID:21657201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3170729/
Abstract

Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.

摘要

吸入单壁碳纳米管（SWCNTs）会引起肺部炎症、损伤和细胞因子网络紊乱。体内局部炎症反应伴随着脾脏 T 细胞增殖减少所证明的系统性免疫改变。体外将未成熟 T 细胞与经 SWCNT 处理的树突状细胞共孵育会降低 T 细胞的增殖。我们的数据表明，体内暴露于 SWCNT 通过调节树突状细胞功能来改变系统性免疫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/04bbdf6206bb/nihms304581f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/194ec4e8e93a/nihms304581f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/e0b071bd0dce/nihms304581f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/e6f9de7f1d91/nihms304581f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/172a264f8ff4/nihms304581f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/04bbdf6206bb/nihms304581f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/194ec4e8e93a/nihms304581f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/e0b071bd0dce/nihms304581f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/e6f9de7f1d91/nihms304581f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/172a264f8ff4/nihms304581f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7025/3170729/04bbdf6206bb/nihms304581f5.jpg

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