碳纳米管对树突状细胞的直接作用导致肺部暴露后免疫抑制。
Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.
机构信息
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
出版信息
ACS Nano. 2011 Jul 26;5(7):5755-62. doi: 10.1021/nn2014479. Epub 2011 Jun 15.
Abstract
Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.
摘要
吸入单壁碳纳米管（SWCNTs）会引起肺部炎症、损伤和细胞因子网络紊乱。体内局部炎症反应伴随着脾脏 T 细胞增殖减少所证明的系统性免疫改变。体外将未成熟 T 细胞与经 SWCNT 处理的树突状细胞共孵育会降低 T 细胞的增殖。我们的数据表明，体内暴露于 SWCNT 通过调节树突状细胞功能来改变系统性免疫。
相似文献
1
Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.碳纳米管对树突状细胞的直接作用导致肺部暴露后免疫抑制。
ACS Nano. 2011 Jul 26;5(7):5755-62. doi: 10.1021/nn2014479. Epub 2011 Jun 15.
2
Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii.肺部暴露于单壁碳纳米管不会影响早期针对弓形虫的免疫反应。
Part Fibre Toxicol. 2012 May 23;9:16. doi: 10.1186/1743-8977-9-16.
3
Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos.考虑碳纳米管和纳米纤维的团聚，以更好地预测它们相对于石棉的毒性。
Part Fibre Toxicol. 2012 Apr 10;9:10. doi: 10.1186/1743-8977-9-10.
4
Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis.C57BL/6小鼠吸入与误吸单壁碳纳米管的比较：炎症、纤维化、氧化应激和诱变
Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L552-65. doi: 10.1152/ajplung.90287.2008. Epub 2008 Jul 25.
5
Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity.依次暴露于碳纳米管和细菌会增强肺部炎症和感染性。
Am J Respir Cell Mol Biol. 2008 May;38(5):579-90. doi: 10.1165/rcmb.2007-0255OC. Epub 2007 Dec 20.
6
Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in mice.在小鼠体内注入单壁碳纳米管、青石棉和超细微碳黑的比较蛋白质组学和肺部毒性研究。
Toxicol Sci. 2011 Mar;120(1):123-35. doi: 10.1093/toxsci/kfq363. Epub 2010 Dec 6.
7
Mouse pulmonary dose- and time course-responses induced by exposure to nitrogen-doped multi-walled carbon nanotubes.暴露于氮掺杂多壁碳纳米管引起的小鼠肺部剂量和时间进程反应。
Inhal Toxicol. 2020 Jan;32(1):24-38. doi: 10.1080/08958378.2020.1723746. Epub 2020 Feb 7.
8
Fibrous nanocellulose, crystalline nanocellulose, carbon nanotubes, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice.在经口吸入后，纤维纳米纤维素、结晶纳米纤维素、碳纳米管和青石棉在小鼠中引发不同的免疫反应。
J Immunotoxicol. 2018 Dec;15(1):12-23. doi: 10.1080/1547691X.2017.1414339.
9
Multi-walled carbon nanotubes activate and shift polarization of pulmonary macrophages and dendritic cells in an model of chronic obstructive lung disease.多壁碳纳米管在慢性阻塞性肺疾病模型中激活和改变肺巨噬细胞和树突状细胞的极化。
Nanotoxicology. 2020 Feb;14(1):77-96. doi: 10.1080/17435390.2019.1663954. Epub 2019 Sep 26.
10
In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotubes.多壁碳纳米管诱导的肺纤维化中T辅助2型驱动的先天性免疫反应的体内激活
Arch Toxicol. 2016 Sep;90(9):2231-2248. doi: 10.1007/s00204-016-1711-1. Epub 2016 Apr 22.
引用本文的文献
1
Nanodiamonds Interact with Primary Human Macrophages and Dendritic Cells Evoking a Vigorous Interferon Response.纳米金刚石与原代人巨噬细胞和树突状细胞相互作用，引发强烈的干扰素反应。
ACS Nano. 2025 May 27;19(20):19057-19079. doi: 10.1021/acsnano.4c18108. Epub 2025 May 14.
2
Unlocking Transplant Tolerance with Biomaterials.利用生物材料实现移植耐受
Adv Healthc Mater. 2025 Feb;14(5):e2400965. doi: 10.1002/adhm.202400965. Epub 2024 Jul 3.
3
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy.肿瘤微环境重塑与癌症免疫治疗中的纳米颗粒。
J Hematol Oncol. 2024 Apr 2;17(1):16. doi: 10.1186/s13045-024-01535-8.
4
Nanomaterials and Their Impact on the Immune System.纳米材料及其对免疫系统的影响。
Int J Mol Sci. 2023 Jan 19;24(3):2008. doi: 10.3390/ijms24032008.
5
Immunotherapeutic nanoparticles: From autoimmune disease control to the development of vaccines.免疫治疗纳米颗粒：从自身免疫性疾病控制到疫苗开发。
Biomater Adv. 2022 Apr;135:212726. doi: 10.1016/j.bioadv.2022.212726. Epub 2022 Apr 22.
6
A New Look at the Effects of Engineered ZnO and TiO Nanoparticles: Evidence from Transcriptomics Studies.工程化氧化锌和二氧化钛纳米颗粒效应的新视角：来自转录组学研究的证据。
Nanomaterials (Basel). 2022 Apr 7;12(8):1247. doi: 10.3390/nano12081247.
7
Coronavirus and Carbon Nanotubes: Seeking Immunological Relationships to Discover Immunotherapeutic Possibilities.冠状病毒和碳纳米管：寻求免疫关系以发现免疫治疗可能性。
Int J Nanomedicine. 2022 Feb 21;17:751-781. doi: 10.2147/IJN.S341890. eCollection 2022.
8
Four Immune-Related Genes (FN1, UGCG, CHPF2 and THBS2) as Potential Diagnostic and Prognostic Biomarkers for Carbon Nanotube-Induced Mesothelioma.四个免疫相关基因（FN1、UGCG、CHPF2和THBS2）作为碳纳米管诱导的间皮瘤的潜在诊断和预后生物标志物
Int J Gen Med. 2021 Aug 29;14:4987-5003. doi: 10.2147/IJGM.S324365. eCollection 2021.
9
Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development.碳纳米管在疫苗开发中的应用进展与展望。
Int J Nanomedicine. 2021 Aug 12;16:5411-5435. doi: 10.2147/IJN.S314308. eCollection 2021.
10
Stimulation of Innate and Adaptive Immune Cells with Graphene Oxide and Reduced Graphene Oxide Affect Cancer Progression.用氧化石墨烯和还原氧化石墨烯刺激天然免疫细胞和适应性免疫细胞会影响癌症进展。
Arch Immunol Ther Exp (Warsz). 2021 Jul 29;69(1):20. doi: 10.1007/s00005-021-00625-6.
本文引用的文献
1
Promoting effects of nanoparticles/materials on sensitive lung inflammatory diseases.纳米颗粒/材料对肺部敏感受性炎症性疾病的促进作用。
Environ Health Prev Med. 2011 May;16(3):139-43. doi: 10.1007/s12199-010-0177-7. Epub 2010 Sep 4.
2
Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies.用天然肺表面活性剂分散单壁碳纳米管进行肺体外和体内毒性研究。
Part Fibre Toxicol. 2010 Oct 19;7:31. doi: 10.1186/1743-8977-7-31.
3
The role of dendritic and epithelial cells as master regulators of allergic airway inflammation.树突状细胞和上皮细胞作为过敏性气道炎症的主调控者的作用。
Lancet. 2010 Sep 4;376(9743):835-43. doi: 10.1016/S0140-6736(10)61226-3.
4
Carbon nanotubes reorganize actin structures in cells and ex vivo.碳纳米管在细胞内和细胞外重组肌动蛋白结构。
ACS Nano. 2010 Aug 24;4(8):4872-8. doi: 10.1021/nn101151x.
5
Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity.单壁碳纳米管的生物相容性纳米级分散体最大限度地降低了体内的肺毒性。
Nano Lett. 2010 May 12;10(5):1664-70. doi: 10.1021/nl9042483.
6
T-cell polarization depends on concentration of the danger signal used to activate dendritic cells.T 细胞的极化依赖于用于激活树突状细胞的危险信号的浓度。
Immunol Cell Biol. 2010 Jul;88(5):537-44. doi: 10.1038/icb.2010.3. Epub 2010 Feb 2.
7
[Gd@C(82)(OH)(22)](n) nanoparticles induce dendritic cell maturation and activate Th1 immune responses.[Gd@C(82)(OH)(22)](n) 纳米颗粒诱导树突状细胞成熟并激活 Th1 免疫应答。
ACS Nano. 2010 Feb 23;4(2):1178-86. doi: 10.1021/nn901478z.
8
Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stress.反复吸入单壁碳纳米管可加重气道过敏性炎症：氧化应激的可能作用。
Free Radic Biol Med. 2010 Apr 1;48(7):924-34. doi: 10.1016/j.freeradbiomed.2010.01.013. Epub 2010 Jan 20.
9
The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes.纳米毒理学在实现纳米医学的“帮助而无害”范式中的作用：来自单壁碳纳米管对肺部影响研究的经验教训。
J Intern Med. 2010 Jan;267(1):106-18. doi: 10.1111/j.1365-2796.2009.02188.x.
10
Mechanisms maintaining peripheral tolerance.维持外周耐受的机制。
Nat Immunol. 2010 Jan;11(1):21-7. doi: 10.1038/ni.1817. Epub 2009 Dec 17.
Zotero 插件