Department of Public Health and Molecular Toxicology, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Environ Health Prev Med. 2011 May;16(3):139-43. doi: 10.1007/s12199-010-0177-7. Epub 2010 Sep 4.
Although the adverse health effects of nanoparticles/materials have been proposed and are being clarified, their facilitating effects on preexisting pathological conditions have not been fully established. We provide insights into the environmental immunotoxicity of nanoparticles as an aggravating factor in hypersusceptible subjects, especially those with respiratory disorders, using our in vivo models. We first examined the effects of nanoparticles/materials on lung inflammation induced by bacterial endotoxin (lipopolysaccharide) as a test model against innate immunity, and demonstrated that nanoparticles instilled through both an intratracheal tube and an inhalation system can exacerbate lung inflammation. Secondly, we examined the effects of nanoparticles/materials on allergic pathophysiology, and showed that repetitive pulmonary exposure to nanoparticles has aggravating effects on allergic airway inflammation, including adjuvant effects on Th2-milieu. Taken together, nanoparticle exposure may synergistically facilitate pathological inflammatory conditions in the lung via both innate and adaptive immunological abnormalities.
虽然纳米颗粒/材料的不良健康影响已经被提出并正在得到阐明，但它们对先前存在的病理状况的促进作用尚未得到充分证实。我们使用体内模型，深入了解纳米颗粒作为一种加重因素对易感性宿主（尤其是患有呼吸障碍的宿主）的环境免疫毒性。我们首先研究了纳米颗粒/材料对细菌内毒素（脂多糖）诱导的肺部炎症的影响，作为针对先天免疫的测试模型，并证明通过气管内管和吸入系统注入的纳米颗粒可加重肺部炎症。其次，我们研究了纳米颗粒/材料对过敏性病理生理学的影响，并表明重复的肺部暴露于纳米颗粒可加重过敏性气道炎症，包括对 Th2 环境的辅助作用。总之，纳米颗粒暴露可能通过先天和适应性免疫异常协同促进肺部的病理性炎症状态。
