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418例肝豆状核变性患者中西医结合治疗的临床分析

[Clinical analysis of 418 patients with Wilson's disease in traditional Chinese medicine and Western medicine therapy].

作者信息

Yang R

机构信息

Department of Neurology, Affiliated Hospital of Anhui of College of TCM, Hefei.

出版信息

Zhong Xi Yi Jie He Za Zhi. 1990 Mar;10(3):134-6, 140, 130.

PMID:2165877
Abstract

From 1974 to 1988, 418 cases of Wilson's disease were treated with TCM-WM in our hospital. 147 cases were of Wilson's type; 149 cases were of pseudosclerosis type; 40 cases were of abdominal and hepatocerebral type; 21 cases were of choreoathetosis type and 21 cases of other types. After a course of treatment for 3 to 6 months, 103 patients showed marked improvement and 286 made some improvement, but no effect was found in 22 patients and 7 deaths were observed. The results were as follows: (1) The mortality in the severe and moderate groups were significantly higher than the mild (P less than 0.05) and the marked effective rate was less than the latter (P less than 0.01). (2) The marked effective rate was lower in abdominal and hepatocerebral type, and no significant difference was found in recovery rate between Wilson's type and pseudosclerosis type.

摘要

1974年至1988年,我院采用中西医结合方法治疗威尔逊氏病418例。其中威尔逊氏型147例;假硬化型149例;腹型及肝脑型40例;舞蹈手足徐动型21例;其他类型21例。经3至6个月的一个疗程治疗后,103例患者显效,286例有好转,但22例无效,7例死亡。结果如下:(1) 重度和中度组的死亡率显著高于轻度组(P<0.05),显效率低于轻度组(P<0.01)。(2) 腹型及肝脑型的显效率较低,威尔逊氏型与假硬化型的恢复率无显著差异。

相似文献

1
[Clinical analysis of 418 patients with Wilson's disease in traditional Chinese medicine and Western medicine therapy].418例肝豆状核变性患者中西医结合治疗的临床分析
Zhong Xi Yi Jie He Za Zhi. 1990 Mar;10(3):134-6, 140, 130.
2
[Treatment of Wilson's disease].[威尔逊氏病的治疗]
Dtsch Med Wochenschr. 1987 Jun 5;112(23):942-3.
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Successful long term oral zinc in florid Wilson's disease: a case report.成功长期口服锌治疗显著型威尔逊病:一例报告
Trop Geogr Med. 1988 Apr;40(2):161-5.
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Penicillamine hepatotoxicity in the treatment of Wilson's disease.青霉胺治疗威尔逊病时的肝毒性。
J Pediatr Gastroenterol Nutr. 1992 Apr;14(3):353-4. doi: 10.1097/00005176-199204000-00021.
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[Treatment of Wilson's disease with Zincteral].用锌剂治疗威尔逊氏病
Neurol Neurochir Pol. 1988 May-Jun;22(3):211-5.
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Pregnancy in a patient with Wilson's disease treated with D-penicillamine and zinc sulfate. A case report and review of the literature.用青霉胺和硫酸锌治疗的威尔逊病患者的妊娠。病例报告及文献复习。
Eur Neurol. 1994;34(6):337-40. doi: 10.1159/000117074.
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[Oral zinc in Wilson disease--an alternative to D-penicillamine].[口服锌剂治疗肝豆状核变性——D-青霉胺的替代疗法]
Z Gastroenterol. 1985 Jan;23(1):25-9.
8
Zinc therapy as the initial treatment for Wilson's disease.锌疗法作为威尔逊氏病的初始治疗方法。
Arch Neurol. 1988 Apr;45(4):373-4. doi: 10.1001/archneur.1988.00520280015007.
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Hemolytic episode in a patient with Wilson's disease treated with zinc.一名接受锌治疗的威尔逊病患者发生溶血发作。
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Two and half years of oral zinc sulphate therapy in an adult patient with Wilson's disease.一名成年威尔逊病患者接受两年半口服硫酸锌治疗。
Pharmacol Res. 1989 Nov-Dec;21 Suppl 1:151-2. doi: 10.1016/s1043-6618(89)80096-9.

引用本文的文献

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Membranous nephropathy caused by dimercaptosuccinic acid in a patient with Wilson's disease: a case report and literature review.Wilson 病患者应用二巯丁二酸导致的膜性肾病:病例报告及文献复习。
BMC Nephrol. 2023 May 26;24(1):147. doi: 10.1186/s12882-023-03201-6.
2
Combined dimercaptosuccinic acid and zinc treatment in neurological Wilson's disease patients with penicillamine-induced allergy or early neurological deterioration.联合二巯丁二酸和锌治疗青霉胺诱导过敏或早期神经恶化的神经型肝豆状核变性患者。
Biosci Rep. 2020 Aug 28;40(8). doi: 10.1042/BSR20200654.