柠檬香精油对小鼠的抗氧化和镇痛作用
Antioxidant and antinociceptive effects of Citrus limon essential oil in mice.
作者信息
Campêlo Lidianne Mayra Lopes, de Almeida Antonia Amanda C, de Freitas Rizângela L Mendes, Cerqueira Gilberto Santos, de Sousa Geane Felix, Saldanha Gláucio Barros, Feitosa Chistiane Mendes, de Freitas Rivelilson Mendes
机构信息
Departmento de Bioquímica e Farmacologia, Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Pesquisa em Neuroquímica Experimental, Núcleo de Tecnologia Farmacêutica, Universidade Federal do Piauí, Teresina, PI 64049-550, Brazil.
出版信息
J Biomed Biotechnol. 2011;2011:678673. doi: 10.1155/2011/678673. Epub 2011 May 31.
The antioxidant and antinociceptive activities of Citrus limon essential oil (EO) were assessed in mice or in vitro tests. EO possesses a strong antioxidant potential according to the scavenging assays. Moreover, it presented scavenger activity against all in vitro tests. Orally, EO (50, 100, and 150 mg/kg) significantly reduced the number of writhes, and, at highest doses, it reduced the number of paw licks. Whereas naloxone antagonized the antinociceptive action of EO (highest doses), this suggested, at least, the participation of the opioid system. Further studies currently in progress will enable us to understand the action mechanisms of EO.
在小鼠体内或体外试验中评估了柠檬香精油（EO）的抗氧化和抗伤害感受活性。根据清除试验，EO具有很强的抗氧化潜力。此外，它在所有体外试验中均表现出清除活性。经口给予EO（50、100和150mg/kg）可显著减少扭体次数，在最高剂量时，还可减少舔足次数。而纳洛酮可拮抗EO（最高剂量）的抗伤害感受作用，这至少提示了阿片样物质系统的参与。目前正在进行的进一步研究将使我们能够了解EO的作用机制。
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