Xavier S M, Barbosa C O, Barros D O, Silva R F, Oliveira A A, Freitas R M
Curso de Farmácia da Faculdade Católica Rainha do Sertão, 660, Centro, Quixadá, 63900-000, Brazil.
Neurosci Lett. 2007 Jun 8;420(1):76-9. doi: 10.1016/j.neulet.2007.04.056. Epub 2007 Apr 29.
Vitamin C (VIT C) is an exogenous antioxidant able to alter the brain oxidative stress. Antioxidant properties have been showed in seizures and status epilepticus (SE) induced by pilocarpine in adult rats. This present study was aimed at was investigating the VIT C effects on latency to first seizure, in percentage of seizures, mortality rate, as well as hippocampal lipid peroxidation levels and catalase activity after seizures and SE. The VIT C effects were investigated after the pretreatment with dose 250 mg/kg, i.p., 30 min before pilocarpine administration (400mg/kg, s.c., pilocarpine group (P400)). The VIT C increase the latency to first seizure and decrease the mortality rate and lipid peroxidation levels. In P400+VIT C and VIT C groups were observed an increase in hippocampal catalase activity. Our results suggests that the vitamin C can exert antioxidant and anticonvulsive effects in adult rats, suggesting that this vitamin can be able by reduction of lipid peroxidation content and increased of catalase enzymatic activity which cerebral compensatory mechanisms in free radical formation during SE.
维生素C（VIT C）是一种外源性抗氧化剂，能够改变大脑的氧化应激。在成年大鼠中，已证明其抗氧化特性在毛果芸香碱诱发的癫痫发作和癫痫持续状态（SE）中发挥作用。本研究旨在调查VIT C对首次癫痫发作潜伏期、癫痫发作百分比、死亡率以及癫痫发作和SE后海马脂质过氧化水平和过氧化氢酶活性的影响。在腹腔注射剂量为250mg/kg的VIT C进行预处理后，于毛果芸香碱给药（皮下注射400mg/kg，毛果芸香碱组（P400））前30分钟，研究VIT C的作用。VIT C可延长首次癫痫发作的潜伏期，降低死亡率和脂质过氧化水平。在P400+VIT C组和VIT C组中，观察到海马过氧化氢酶活性增加。我们的结果表明，维生素C在成年大鼠中可发挥抗氧化和抗惊厥作用，这表明该维生素可通过降低脂质过氧化含量和增加过氧化氢酶活性来发挥作用，而这是SE期间大脑自由基形成中的一种脑补偿机制。
