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肾移植受者丙型肝炎病毒感染的困境

Dilemma of HCV infection in renal transplant recipients.

作者信息

Ashry Ahmed Gheith Osama

机构信息

Urology and Nephrology Center, Mansoura University, Gomhoria Street, Mansoura, Egypt.

出版信息

Int J Nephrol. 2011;2011:471214. doi: 10.4061/2011/471214. Epub 2011 May 25.

Abstract

Hepatitis C virus, which usually starts during dialysis therapy, is currently the main cause of chronic liver disease in such population. The majority of patients acquired the disease through intravenous drug use or blood transfusion, with some risk factors identified. In this review we are dealing with the effect of renal transplantation on HCV infection and HCV-related complications after renal transplantation. Moreover, we are discussing the therapeutic options of HCV infection before and after renal transplantation, the best immunosuppressive protocol and lastly graft and patient survival in patients who underwent pretransplant management vs. those who were transplanted without treatment.

摘要

丙型肝炎病毒通常在透析治疗期间开始感染,目前是这类人群慢性肝病的主要病因。大多数患者是通过静脉注射吸毒或输血感染该疾病的,并且已经确定了一些危险因素。在本综述中,我们探讨肾移植对丙型肝炎病毒感染以及肾移植后丙型肝炎病毒相关并发症的影响。此外,我们还讨论了肾移植前后丙型肝炎病毒感染的治疗选择、最佳免疫抑制方案,最后讨论了接受移植前管理的患者与未经治疗即接受移植的患者的移植物和患者生存率。

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本文引用的文献

2
Pegylated interferon-alpha-based treatment for chronic hepatitis C in renal transplant recipients: an open pilot study.
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