Torres Juan, Aguado Jose María, San Juan Rafael, Andrés Amado, Sierra Prado, López-Medrano Francisco, Morales Jose María
Unit of Infectious Diseases and Renal Transplantation, Department of Nephrology, University Hospital 12 de Octubre, Madrid, Spain.
Transpl Int. 2008 Sep;21(9):873-8. doi: 10.1111/j.1432-2277.2008.00694.x. Epub 2008 May 13.
Little is known about the role of hepatitis C virus (HCV) infection in the development of tuberculosis (TB) in patients with immunosuppression. We performed a retrospective case-control study (1:4) to investigate by univariate and multivariate logistic regression analysis the importance of HCV infection in the development of TB in a cohort of kidney transplant recipients (KTR). TB was diagnosed in 16 out of 2012 (0.8%) KTR between 1976 and 2004. The percentage of HCV-positive patients was significantly higher in cases than in controls (56.3% vs. 18.8%; P=0.02). By multivariate analysis, the only two independent risk factors associated with the development of TB were the presence of HCV infection (P=0.003; OR=6.5; 95% CI 1.9-23) and serum creatinine over 1.5 mg/dl (P=0.03; OR=4.8; 95% CI 1.1-21). HCV infection and chronic graft dysfunction are important risks factors for TB in KTR.
关于丙型肝炎病毒（HCV）感染在免疫抑制患者发生结核病（TB）过程中的作用，目前所知甚少。我们进行了一项回顾性病例对照研究（1:4），通过单因素和多因素逻辑回归分析，调查HCV感染在一组肾移植受者（KTR）发生TB过程中的重要性。在1976年至2004年间，2012名KTR中有16名（0.8%）被诊断为TB。病例组中HCV阳性患者的百分比显著高于对照组（56.3%对18.8%；P=0.02）。通过多因素分析，与发生TB相关的仅有的两个独立危险因素是HCV感染（P=
