Papadogeorgakis Nick, Kalfarentzos Evagelos F, Petsinis Vassilis, Parara Eleni, Kopaka Maria-Emmanouela
Department of Oral and Maxillofacial Surgery, Evangelismos General Hospital, University of Athens Dental School, 45-47 Ipsilantou Street, Athens 10676, Greece.
Oral Maxillofac Surg. 2012 Mar;16(1):137-40. doi: 10.1007/s10006-011-0279-4. Epub 2011 Jun 10.
Pleomorphic adenoma is the most common neoplasm of the parotid gland. It is a benign tumor composed of epithelial and myoepithelial cells arranged in various morphological patterns. The most common reasons contributing to a recurrent disease are obvious or underestimated tumor spillage, incomplete excision, and violation of the pseudocapsule of the tumor.
This article presents a case of gross multinodular recurrence of a parotid gland pleomorphic adenoma in a 38-year-old female patient. Upon clinical examination of the homolateral neck, multiple, painless, well-defined, palpable, nontender masses and subcutaneous nodules of the right parotid and homolateral neck region were revealed. The patient was treated with surgery and subsequent radiation therapy. Histologic examination of the resected specimen was suggestive of a recurrent pleomorphic adenoma disease. There were no signs of malignant transformation in the specimen. The diagnostic procedure followed, and management of the patient is outlined in the paper.
Pleomorphic adenoma is the most common tumor of the parotid gland. In spite of being a benign neoplasm, inadequate management of the lesion may lead to problems such as local recurrence or malignant transformation. Management of recurrent tumors is challenging because the probability of subsequent recurrence increases with each recurrent episode, thus making local control increasingly difficult and damage to the facial nerve more likely.
多形性腺瘤是腮腺最常见的肿瘤。它是一种由上皮细胞和肌上皮细胞以各种形态模式排列组成的良性肿瘤。导致疾病复发的最常见原因是明显的或被低估的肿瘤溢出、切除不完全以及侵犯肿瘤的假包膜。
本文介绍了一名38岁女性患者腮腺多形性腺瘤出现肉眼可见的多结节复发的病例。对同侧颈部进行临床检查时,发现右侧腮腺和同侧颈部区域有多个无痛、边界清晰、可触及、无压痛的肿块及皮下结节。该患者接受了手术及后续放疗。对切除标本的组织学检查提示为复发性多形性腺瘤疾病。标本中未发现恶变迹象。文中介绍了所采用的诊断程序及患者的治疗情况。
多形性腺瘤是腮腺最常见的肿瘤。尽管它是良性肿瘤,但对该病变处理不当可能导致局部复发或恶变等问题。复发性肿瘤的治疗具有挑战性,因为随着每次复发,后续复发的可能性会增加,从而使局部控制越来越困难,面神经受损的可能性也更大。